The duplication of the eukaryotic genome is an intricate process that has to be tightly safe‐
guarded. One of the most frequently occurring errors during DNA synthesis is the mis …

The gastrointestinal tract is a highly complex microenvironment under constant interaction
with potentially harmful pathogens. Inflammatory bowel disease (IBD) is an archetypical …

The comorbid association of autoimmune diseases with cancers has been a major obstacle
to successful anti-cancer treatment. Cancer survival rate decreases significantly in patients …

Pattern-recognition receptors (PRRs) are critical to recognizing endogenous and exogenous
threats to mount a protective proinflammatory innate immune response. PRRs may be …

Cellular senescence caused by oncogenic stimuli is associated with the development of
various age-related pathologies through the senescence-associated secretory phenotype …

Abundant ribonucleoside-triphosphate (rNTP) incorporation into DNA by DNA polymerases
in the form of ribonucleoside monophosphates (rNMPs) is a widespread phenomenon in …

Background & Aims Throughout life, the intestinal epithelium undergoes constant self-
renewal from intestinal stem cells. Together with genotoxic stressors and failing DNA repair …

The mutational landscape is shaped by many processes. Genic regions are vulnerable to
mutation but are preferentially protected by transcription-coupled repair. In microorganisms …

Ribonucleotides are the most abundant non-canonical nucleotides in the genome. Their
vast presence and influence over genome biology is becoming increasingly appreciated …

Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with complex causes.
The main pathological changes were intestinal mucosal injury. Leucine-rich repeat …