[HTML][HTML] Microglia and astrocytes underlie neuroinflammation and synaptic susceptibility in autism spectrum disorder

Y Xiong, J Chen, Y Li - Frontiers in Neuroscience, 2023 - frontiersin.org
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with onset in
childhood. The mechanisms underlying ASD are unclear. In recent years, the role of …

[HTML][HTML] Postsynaptic autism spectrum disorder genes and synaptic dysfunction

P Bonsi, A De Jaco, L Fasano, P Gubellini - Neurobiology of disease, 2022 - Elsevier
This review provides an overview of the synaptic dysfunction of neuronal circuits and the
ensuing behavioral alterations caused by mutations in autism spectrum disorder (ASD) …

[HTML][HTML] Modern biomarkers for autism spectrum disorder: future directions

AR Jensen, AL Lane, BA Werner, SE McLees… - Molecular Diagnosis & …, 2022 - Springer
Autism spectrum disorder is an increasingly prevalent neurodevelopmental disorder in the
world today, with an estimated 2% of the population being affected in the USA. A major …

[HTML][HTML] Mitochondrial morphology is associated with respiratory chain uncoupling in autism spectrum disorder

RE Frye, L Lionnard, I Singh, MA Karim… - Translational …, 2021 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is associated with
unique changes in mitochondrial metabolism, including elevated respiration rates and …

[HTML][HTML] Increased maternal non-oxidative energy metabolism mediates association between prenatal di-(2-ethylhexyl) phthalate (DEHP) exposure and offspring …

S Thomson, K Drummond, M O'Hely… - Environment …, 2023 - Elsevier
Prenatal phthalate exposure has previously been linked to the development of autism
spectrum disorder (ASD). However, the underlying biological mechanisms remain unclear …

[HTML][HTML] Treatment of autism spectrum disorders by mitochondrial-targeted drug: Future of neurological diseases therapeutics

SU Nabi, MU Rehman, A Arafah, S Taifa… - Current …, 2023 - ncbi.nlm.nih.gov
Autism is a neurodevelopmental disorder with a complex etiology that might involve
environmental and genetic variables. Recently, some epidemiological studies conducted in …

[HTML][HTML] Diet in treatment of autism spectrum disorders

S Alam, CJ Westmark, EA McCullagh - Frontiers in neuroscience, 2023 - frontiersin.org
Altering the diet to treat disease dates to c. 400 BC when starvation was used to reduce
seizures in persons with epilepsy. The current diversity of symptomology and mechanisms …

Impacts of Gestational FireMaster 550 Exposure on the Neonatal Cortex Are Sex Specific and Largely Attributable to the Organophosphate Esters

SK Witchey, MG Doyle, JD Fredenburg… - …, 2023 - karger.com
Abstract Introduction: Flame retardants (FRs) are common bodily and environmental
pollutants, creating concern about their potential toxicity. We and others have found that the …

[HTML][HTML] Ways to address perinatal mast cell activation and focal brain inflammation, including response to SARS-CoV-2, in autism spectrum disorder

TC Theoharides - Journal of Personalized Medicine, 2021 - mdpi.com
The prevalence of autism spectrum disorder (ASD) continues to increase, but no distinct
pathogenesis or effective treatment are known yet. The presence of many comorbidities …

[HTML][HTML] Bioenergetic signatures of neurodevelopmental regression

RE Frye, PJ McCarty, BA Werner, S Rose… - Frontiers in …, 2024 - frontiersin.org
Background: Studies have linked autism spectrum disorder (ASD) to physiological
abnormalities including mitochondrial dysfunction. Mitochondrial dysfunction may be linked …