Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

Biological energy transduction underlies all physiological phenomena in cells. The
metabolic systems that support energy transduction have been of great interest due to their …

Protein film electrochemistry (PFE) has given unrivalled insight into the properties of redox
proteins and many electron-transferring enzymes, allowing investigations of otherwise ill …

Mitochondria sense both biochemical and energetic input in addition to communicating
signals regarding the energetic state of the cell. Increasingly, these signaling organelles are …

Our current understanding of variation in mitochondrial performance is incomplete. The
production of ATP via oxidative phosphorylation is dependent, in part, on the structure of the …

The adaptive plasticity of mitochondria within a skeletal muscle is regulated by signals
converging on a myriad of regulatory networks that operate during conditions of increased …

Across different cell types and within single cells, mitochondria are heterogeneous in form
and function. In skeletal muscle cells, morphologically and functionally distinct …

This review summarizes the current understanding of the role of plasma membrane
transporters in regulating intracellular inorganic phosphate ([Pi] In) in mammals. Pi influx is …

Sustained muscle contraction occurs through interactions between actin and myosin
filaments within sarcomeres and requires a constant supply of adenosine triphosphate (ATP) …