Accumulating data indicate that oxidative stress (OS) plays a major role in the pathogenesis
of multiple sclerosis (MS). Reactive oxygen species (ROS), leading to OS, generated in …

Nitric oxide (NO) is a colorless gas at room temperature and one of the simplest molecules
known, yet it has been implicated in a wide variety of regulatory mechanisms ranging from …

Uric acid, the naturally occurring product of purine metabolism, is a strong peroxynitrite
scavenger, as demonstrated by the capacity to bind peroxynitrite but not nitric oxide (NO) …

This review summarises the role that reactive oxygen and nitrogen species play in
demyelination, such as that occurring in the inflammatory demyelinating disorders multiple …

Thymoquinone (TQ) is the major active compound derived from Nigella sativa. Our aim of
this work was to evaluate the antioxidant and antiarthritic activity of TQ in Wistar rat by …

Multiple sclerosis is a neurologic disease caused by immune cell infiltration into the central
nervous system, resulting in gray and white matter inflammation, progressive demyelination …

Proinflammatory cytokines, tumour necrosis factor (TNF)-α, interferon (IFN)-γ and interleukin
(IL)-6, have multiple effects in the central nervous system (CNS) not strictly cytotoxic being …

Glaucoma is an optic neuropathy with cupping of the optic disk, degeneration of retinal
ganglion cells, and characteristic visual field loss. Because elevated intraocular pressure …

The importance of transforming growth factor-beta-1 (TGF-β1) in immunoregulation and
tolerance has been increasingly recognized. It is now proposed that there are populations of …

The pathophysiology of multiple sclerosis (MS) involves several components: redox,
inflammatory/autoimmune, vascular, and neurodegenerative. All of them are supported by …