Imaging has played a variety of roles in the study of Alzheimer disease (AD) over the past
four decades. Initially, computed tomography (CT) and then magnetic resonance imaging …

Lower brain glucose metabolism is present before the onset of clinically measurable
cognitive decline in two groups of people at risk of Alzheimer's disease---carriers of …

Currently available evidence strongly supports the position that the initiating event in
Alzheimer's disease (AD) is related to abnormal processing of β-amyloid (Aβ) peptide …

A cross-sectional group study of the effects of aging on brain metabolism as measured with
18 F-FDG-PET was performed using several different partial volume correction (PVC) …

Fluorodeoxyglucose positron emission tomography (PET) studies have found that patients
with Alzheimer's dementia (AD) have abnormally low rates of cerebral glucose metabolism …

We describe a new magnetic resonance (MR) image analysis tool that produces cortical
surface representations with spherical topology from MR images of the human brain. The …

The demographics of aging suggest a great need for the early diagnosis of dementia and
the development of preventive strategies. Neuropathology and structural MRI studies have …

Objective: To evaluate the total number of synapses in the stratum radiatum (str rad) of the
human hippocampal CA1 subfield in individuals with mild Alzheimer disease (mAD), mild …

We describe a sequence of low-level operations to isolate and classify brain tissue within T1-
weighted magnetic resonance images (MRI). Our method first removes nonbrain tissue …

The integrity of mitochondrial function is fundamental to cell life. It follows that disturbances
of mitochondrial function will lead to disruption of cell function, expressed as disease or …