[HTML][HTML] Cancer stem cells in immunoregulation and bypassing anti-checkpoint therapy
E Rouzbahani, J Majidpoor, S Najafi… - Biomedicine & …, 2022 - Elsevier
Tumor microenvironment (TME) takes critical roles in tumor resistance to immune checkpoint
inhibitors (ICIs) including anti-programmed death-1 (PD-1) or anti-programmed death-ligand …
inhibitors (ICIs) including anti-programmed death-1 (PD-1) or anti-programmed death-ligand …
Towards targeting the breast cancer immune microenvironment
The tumour immune microenvironment is shaped by the crosstalk between cancer cells,
immune cells, fibroblasts, endothelial cells and other stromal components. Although the …
immune cells, fibroblasts, endothelial cells and other stromal components. Although the …
Engineered exosomes as an in situ DC-primed vaccine to boost antitumor immunity in breast cancer
L Huang, Y Rong, X Tang, K Yi, P Qi, J Hou, W Liu… - Molecular cancer, 2022 - Springer
Abstract Background Dendritic cells (DCs) are central for the initiation and regulation of
innate and adaptive immunity in the tumor microenvironment. As such, many kinds of DC …
innate and adaptive immunity in the tumor microenvironment. As such, many kinds of DC …
Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer
F Wu, J Fan, Y He, A Xiong, J Yu, Y Li, Y Zhang… - Nature …, 2021 - nature.com
Lung cancer is a highly heterogeneous disease. Cancer cells and cells within the tumor
microenvironment together determine disease progression, as well as response to or …
microenvironment together determine disease progression, as well as response to or …
CD8 T cell score as a prognostic biomarker for triple negative breast cancer
CD8 T cell is an essential component of tumor-infiltrating lymphocytes (TIL) and tumor
immune microenvironment (TIME). Using the xCell CD8 T cell score of whole tumor gene …
immune microenvironment (TIME). Using the xCell CD8 T cell score of whole tumor gene …
[HTML][HTML] UVB-induced tumor heterogeneity diminishes immune response in melanoma
Although clonal neo-antigen burden is associated with improved response to immune
therapy, the functional basis for this remains unclear. Here we study this question in a novel …
therapy, the functional basis for this remains unclear. Here we study this question in a novel …
Development and validation of a combined ferroptosis and immune prognostic classifier for hepatocellular carcinoma
Y Liu, X Zhang, J Zhang, J Tan, J Li… - Frontiers in cell and …, 2020 - frontiersin.org
Background Immunotherapy and sorafenib exert anti-tumor effects via ferroptosis, but
reliable biomarkers for the individual treatment and prognosis prediction of hepatocellular …
reliable biomarkers for the individual treatment and prognosis prediction of hepatocellular …
G2M cell cycle pathway score as a prognostic biomarker of metastasis in estrogen receptor (ER)-positive breast cancer
The vast majority of breast cancer death is a result of metastasis. Thus, accurate
identification of patients who are likely to have metastasis is expected to improve survival …
identification of patients who are likely to have metastasis is expected to improve survival …
MYC targets scores are associated with cancer aggressiveness and poor survival in ER-positive primary and metastatic breast cancer
MYC is one of the most studied oncogenes that is known to promote cell proliferation. We
utilized MYC targets v1 and MYC targets v2 scores of gene set variation analysis and …
utilized MYC targets v1 and MYC targets v2 scores of gene set variation analysis and …
[HTML][HTML] KRAS signaling enriched triple negative breast cancer is associated with favorable tumor immune microenvironment and better survival
KRAS signaling is associated with cancer progression in several cancers. Upregulation of
KRAS signaling is often seen in cancers that harbor high KRAS mutation rate, such as …
KRAS signaling is often seen in cancers that harbor high KRAS mutation rate, such as …