An ensemble of in vitro cardiac tissue models has been developed over the past several
decades to aid our understanding of complex cardiovascular disorders using a reductionist …

Engineered human cardiac tissues facilitate progress in regenerative medicine, disease
modelling and drug development. In this Perspective, we reflect on the most notable …

Heart disease is a worldwide health menace. Both intractable primary and secondary
cardiomyopathies contribute to malignant cardiac dysfunction and mortality. One of the key …

Abstract Doxorubicin (DOX)‐induced cardiotoxicity (DoIC) is a major side effect for cancer
patients. Recently, ferroptosis, triggered by iron overload, is demonstrated to play a role in …

Induced pluripotent stem cells (iPSCs) have emerged as a key component of cardiac tissue
engineering, enabling studies of cardiovascular disease mechanisms, drug responses, and …

In vitro modelling the complex (patho‐) physiological conditions of the heart is a major
challenge in cardiovascular research. In recent years, methods based on three‐dimensional …

Mitochondrial cardiomyopathies are fatal diseases, with no effective treatment. Alterations of
heart mitochondrial function activate the mitochondrial integrated stress response (ISR mt), a …

Abstract Background Amorphous silica nanoparticles (SiNPs) have been gradually proven
to threaten cardiac health, but pathogenesis has not been fully elucidated. Ferroptosis is a …

Selectively ablating damaged cells is an evolving therapeutic approach for age-related
disease. Current methods for genome-wide screens to identify genes whose deletion might …

Drug-induced cardiotoxicity is a significant clinical issue, with many drugs in the market
being labeled with warnings on cardiovascular adverse effects. Treatments are often …