Lung organoids—the ultimate tool to dissect pulmonary diseases?

V Bosáková, M De Zuani, L Sládková… - Frontiers in Cell and …, 2022 - frontiersin.org
Organoids are complex multicellular three-dimensional (3D) in vitro models that are
designed to allow accurate studies of the molecular processes and pathologies of human …

Developments in mass spectrometry for glycosaminoglycan analysis: a review

LE Pepi, P Sanderson, M Stickney, IJ Amster - Molecular & Cellular …, 2021 - ASBMB
This review covers recent developments in glycosaminoglycan (GAG) analysis via mass
spectrometry (MS). GAGs participate in a variety of biological functions, including cellular …

Adrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19

T Paul, S Ledderose, H Bartsch, N Sun… - Nature …, 2022 - nature.com
Progressive respiratory failure and hyperinflammatory response is the primary cause of
death in the coronavirus disease 2019 (COVID-19) pandemic. Despite mounting evidence of …

The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling

M Ackermann, JC Kamp, C Werlein, CL Walsh… - …, 2022 - thelancet.com
Background COVID-19 is characterized by a heterogeneous clinical presentation, ranging
from mild symptoms to severe courses of disease. 9–20% of hospitalized patients with …

Multiplexed imaging mass spectrometry of the extracellular matrix using serial enzyme digests from formalin-fixed paraffin-embedded tissue sections

CL Clift, RR Drake, A Mehta, PM Angel - Analytical and bioanalytical …, 2021 - Springer
We report a multiplexed imaging mass spectrometry method which spatially localizes and
selectively accesses the extracellular matrix on formalin-fixed paraffin-embedded tissue …

Mapping the metabolomic and lipidomic changes in the bleomycin model of pulmonary fibrosis in young and aged mice

J Weckerle, S Picart-Armada, S Klee… - Disease models & …, 2022 - journals.biologists.com
Alterations in metabolic pathways were recently recognized as potential underlying drivers
of idiopathic pulmonary fibrosis (IPF), translating into novel therapeutic targets. However …

18F-AzaFol for Detection of Folate Receptor-β Positive Macrophages in Experimental Interstitial Lung Disease—A Proof-of-Concept Study

J Schniering, M Benešová, M Brunner, S Haller… - Frontiers in …, 2019 - frontiersin.org
Background: Interstitial lung disease (ILD) is a common and severe complication in
rheumatic diseases. Folate receptor-β is expressed on activated, but not resting …

Patterns of carbon-bound exogenous compounds in patients with lung cancer and association with disease pathophysiology

T Kunzke, VM Prade, A Buck, N Sun, A Feuchtinger… - Cancer research, 2021 - AACR
Asymptomatic anthracosis is the accumulation of black carbon particles in adult human
lungs. It is a common occurrence, but the pathophysiologic significance of anthracosis is …

[HTML][HTML] Spatial metabolomics reveals upregulation of several pyrophosphate-producing pathways in cortical bone of Hyp mice

A Buck, VM Prade, T Kunzke, RG Erben, A Walch - JCI insight, 2022 - ncbi.nlm.nih.gov
Patients with the renal phosphate–wasting disease X-linked hypophosphatemia (XLH) and
Hyp mice, the murine homolog of XLH, are characterized by loss-of-function mutations in …

Piceatannol is superior to resveratrol at suppressing adipogenesis in human visceral adipose-derived stem cells

IS Park, Y Han, HA Jo, KW Lee, YS Song - Plants, 2021 - mdpi.com
Resveratrol (3, 4′, 5-trans-trihydroxystilbene) and piceatannol (3, 3′, 4′, 5-trans-
tetraphydroxystilbene) are major stilbene compounds that are predominantly present in …