Diseases are manifestations of complex changes in protein–protein interaction (PPI)
networks whereby stressors, genetic, environmental, and combinations thereof, alter …

Radiation therapy remains an important component of cancer treatment. Gene-encoded
proteins were the actual executors of cellular functions. Proteomic was a novel technology …

Identifying essential genes and proteins is a critical step towards a better understanding of
human biology and pathology. Computational approaches helped to mitigate experimental …

Background Recent advances in single-cell RNA sequencing have allowed researchers to
explore transcriptional function at a cellular level. In particular, single-cell RNA sequencing …

Cancer cell dysregulations result in the abnormal regulation of cellular metabolic pathways.
By simulating this metabolic reprogramming using constraint‐based modeling approaches …

Although cancer has historically been regarded as a cell proliferation disorder, it has
recently been considered a metabolic disease. The first discovery of metabolic alterations in …

In fact, the risk of dying from CVD is significant when compared to the risk of developing end-
stage renal disease (ESRD). Moreover, patients with severe CKD are often excluded from …

It is becoming evident that holistic perspectives toward cancer are crucial in deciphering the
overwhelming complexity of tumors. Single-layer analysis of genome-wide data has greatly …

The objective of this study was to fully describe the protocol with standardized modifications
and evaluate the lysozyme activity, an indicator of innate immunity in tilapia, to compare …

Hutchinson-Gilford progeria syndrome (HGPS) is a very rare fatal disease characterized for
accelerated aging. Although the causal agent, a point mutation in LMNA gene, was …