Biomaterial-based scaffolds–current status and future directions

T Garg, AK Goyal - Expert opinion on drug delivery, 2014 - Taylor & Francis
Introduction: Biomaterial-based scaffold formulations (three-dimensional Porous matrix,
nano-fibre mesh, hydrogels and microspheres) are the major components that are used to …

Combining nanotechnology with monoclonal antibody drugs for rheumatoid arthritis treatments

XK Chi, XL Xu, BY Chen, J Su, YZ Du - Journal of Nanobiotechnology, 2023 - Springer
Rheumatoid arthritis (RA) is a systemic immune disease characterized by synovial
inflammation. Patients with RA commonly experience significant damage to their hand and …

Trigger-responsive engineered-nanocarriers and image-guided theranostics for rheumatoid arthritis

N Ahamad, A Prabhakar, S Mehta, E Singh, E Bhatia… - Nanoscale, 2020 - pubs.rsc.org
Rheumatoid Arthritis (RA), one of the leading causes of disability due to progressive
autoimmune destruction of synovial joints, affects∼ 1% of the global population. Standard …

Approaches to creating and past successful attempts on microspheres: A primer for aspiring researchers

K Sailaja, HA Ahad, H Chinthaginjala… - Research Journal of …, 2022 - search.proquest.com
A targeted drug delivery system is intended to increase the concentration of medication in
the areas of interest while reducing its concentration in the rest of the body.[...] the drug is …

Effect of thermal and shear stressors on the physical properties, structural integrity and biological activity of the anti-TNF-alpha monoclonal antibody, infliximab

J A. Alsaddique, R M. Pabari… - Current pharmaceutical …, 2016 - benthamdirect.com
The influence of thermal and shear stressors on the stability of the anti-TNF-α monoclonal
antibody (mAb), Infliximab®(INF) was investigated. INF at concentrations of 1, 4 and 10 …

Physicochemical characterization of spray-dried PLGA/PEG microspheres, and preliminary assessment of biological response

C Javiya, S Jonnalagadda - Drug development and industrial …, 2016 - Taylor & Francis
Context: The use of spray-drying to prepare blended PLGA: PEG microspheres with lower
immune detection. Objective: To study physical properties, polymer miscibility and alveolar …

An ameliorated anti-hTNF-α therapy for arthritis via carrier-free macromolecular nanoparticles consisted of infliximab

Y Li, X Wang, B He, H Zhang, W Dai, G Li… - International Journal of …, 2023 - Elsevier
Infliximab (INF) is intravenously used for the clinical treatment of rheumatoid arthritis.
However, it can cause serious side effects, which are mainly associated with systemic …

Biofunctional nanofibrous substrate for local TNF-capturing as a strategy to control inflammation in arthritic joints

E Bacelo, M Alves da Silva, C Cunha, S Faria… - Nanomaterials, 2019 - mdpi.com
Rheumatoid arthritis (RA) is an autoimmune disease that affects the synovial cavity of joints,
and its pathogenesis is associated with an increased expression of pro-inflammatory …

Infliximab microencapsulation: an innovative approach for intra-articular administration of biologics in the management of rheumatoid arthritis—in vitro evaluation

I Lamela-Gómez, LM Gonçalves, AJ Almeida… - Drug Delivery and …, 2023 - Springer
Microencapsulation of the therapeutical monoclonal antibody infliximab (INF) was
investigated as an innovative approach to improve its stability and to achieve formulations …

[图书][B] Metodología Elisa para estudiar la estabilidad de medicamentos biotecnológicos

I Suárez González - 2017 - digibug.ugr.es
Los fármacos biotecnológicos son medicamentos obtenidos a partir de tecnología del ADN
recombinante o de la expresión controlada de genes que codifican proteínas …