Androgens, acting through the androgen receptor (AR), are responsible for the development
of the male phenotype during embryogenesis, the achievement of sexual maturation at …

The activation of nuclear factor-kappaB (NFΚB), a proinflammatory transcription factor, is a
commonly observed phenomenon in breast cancer. It facilitates the development of a …

The androgen receptor (AR) is a key regulator of prostate tumorgenesis through actions that
are not fully understood. We identified the repressor element (RE)-1 silencing transcription …

c-Rel is a member of the nuclear factor κB (NF-κB) transcription factor family. Unlike other NF-
κB proteins that are expressed in a variety of cell types, high levels of c-Rel expression are …

Abstract Prostate Cancer (PCa) is the second leading cause of cancer-related death in men.
Adenocarcinoma of the prostate is primarily composed of Androgen Receptor-positive (AR+) …

Prostate cancer is a highly prevalent form of cancer that is usually slow-developing and
benign. Due to its high prevalence, it is, however, still the second most common cause of …

Circadian genes influence a variety of biological processes that are important in prostate
tumorigenesis including metabolism. To determine if variants in circadian genes alter …

Glucocorticoid receptor (GR) and androgen receptor (AR) are steroid-inducible transcription
factors (TFs). The GR and the AR are central regulators of various metabolic, homeostatic …

The androgen receptor (AR) is essential for diverse aspects of prostate development and
function. Molecular mechanisms by which prostate cancer (PC) cells redirect AR signaling to …

Epididymal function depends on androgen signaling through the androgen receptor (AR),
although most of the direct AR target genes in epididymis remain unknown. Here we …