Chiral metal-organic frameworks and their composites as stationary phases for liquid chromatography chiral separation: a minireview

C Liu, K Quan, J Chen, X Shi, H Qiu - Journal of Chromatography A, 2023 - Elsevier
Chiral metal organic frameworks (CMOFs) are a kind of crystal porous framework material
that has attracted increasing attention due to the customizable combination of metal nodes …

One reaction–double stereoinduction: C–H activation as a privileged route towards complex atropisomeric molecules

A Luc, J Wencel-Delord - Chemical Communications, 2023 - pubs.rsc.org
Expanding the importance of chirality and implementation of stereogenic information within
complex molecular design has recently reached a new level: design of innovative …

Multifaceted view on the mechanism of a photochemical deracemization reaction

RJ Kutta, J Großkopf, N van Staalduinen… - Journal of the …, 2023 - ACS Publications
Upon irradiation in the presence of a chiral benzophenone catalyst (5 mol%), a racemic
mixture of a given chiral imidazolidine-2, 4-dione (hydantoin) can be converted almost …

Double cobalt-catalyzed atroposelective C–H activation: One-step synthesis of atropisomeric indoles bearing vicinal C–C and C–N diaxes

A Luc, JCA Oliveira, P Boos, N Jacob, L Ackermann… - Chem Catalysis, 2023 - cell.com
Expanding the borders of asymmetric synthesis by designing original chiral molecules and
sustainable strategies to synthesize them holds great promise not only for the …

Phytochemicals involved in mitigating silent toxicity induced by heavy metals

J Ceramella, AC De Maio, G Basile, A Facente, E Scali… - Foods, 2024 - mdpi.com
Heavy metals (HMs) are natural elements present in the Earth's crust, characterised by a
high atomic mass and a density more than five times higher than water. Despite their origin …

Chirality of new drug approvals (2013–2022): trends and perspectives

RU McVicker, NM O'Boyle - Journal of Medicinal Chemistry, 2024 - ACS Publications
Many drugs are chiral with their chirality determining their biological interactions, safety, and
efficacy. Since the 1980s, there has been a regulatory preference to bring single enantiomer …

Impact of cytochrome P450 enzymes on the phase I metabolism of drugs

D Iacopetta, J Ceramella, A Catalano, E Scali… - Applied Sciences, 2023 - mdpi.com
The cytochrome P450 (CYP) enzyme family is the major enzyme system catalyzing the
phase I metabolism of xenobiotics, including pharmaceuticals and toxic compounds in the …

Microwave Three-Wave Mixing Spectroscopy of Chiral Molecules in Weakly Bound Complexes

W Sun, M Schnell - The Journal of Physical Chemistry Letters, 2023 - ACS Publications
Since the first experimental implementation in 2013, microwave three-wave mixing has
emerged as a robust spectroscopic approach for analyzing and controlling chiral molecules …

Postsynthetic Modification Strategy for Constructing Electrochemiluminescence-Active Chiral Covalent Organic Frameworks Performing Efficient Enantioselective …

L Tan, W Cai, F Wang, J Li, D Wu, Y Kong - Analytical Chemistry, 2024 - ACS Publications
Electrochemiluminescence (ECL), integrating the characteristics of electrochemistry and
fluorescence, has the advantages of high sensitivity and low background. However, only a …

Negative Nonlinear CD–ee Dependence in Polycrystalline BINOL Thin Films

K Liang, F Ristow, K Li, J Pittrich, N Fehn… - Journal of the …, 2023 - ACS Publications
Generally, the relationship between the observed circular dichroism and the enantiomeric
excess in chiral systems (CD–ee dependence) is linear. While positive nonlinear behavior …