Microbes with complex functions have been found to be a potential component in tumor
microenvironments. Due to their low biomass and other obstacles, intratumor microbiota is …

Biological membranes play a crucial role in actively hosting, modulating and coordinating a
wide range of molecular events essential for cellular function. Membranes are organized …

We report the rational engineering of a remarkably stable yellow fluorescent protein
(YFP),'hyperfolder YFP'(hfYFP), that withstands chaotropic conditions that denature most …

Virus assembly, which takes place during the late stage of viral replication, is essential for
virus propagation. However, the underlying mechanisms remain poorly understood …

Stimulated emission depletion (STED) nanoscopy is an emerging super-resolution imaging
platform for the study of the cellular structure. Developing suitable fluorescent probes of …

Correlative light and electron microscopy (CLEM) is a powerful imaging approach that
allows the direct correlation of information obtained on a light and an electron microscope …

Pioneer transcription factors (PTFs) possess the unique capability to access closed
chromatin regions and initiate cell fate changes, yet the underlying mechanisms remain …

Optical fluorescence microscopy plays a pivotal role in the exploration of biological structure
and dynamics, especially on live specimens. Progress in the field relies, on the one hand, on …

Volume electron microscopy (vEM) generates large 3D volumes of cells or tissues at
nanoscale resolutions, enabling analyses of organelles in their cellular environment. Here …

Nanoparticles (NPs) are used to encapsulate therapeutic cargos and deliver them
specifically to the target site. The intracellular trafficking of NPs dictates the NP-cargo …