It is remarkable how robustly a bacterial species can maintain its preferred size. This
capacity is intimately related to control of the cell cycle: cell size and growth rate determine …

Most microorganisms regulate their cell size. In this article, we review some of the
mathematical formulations of the problem of cell size regulation. We focus on coarse …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Many experiments show that the numbers of mRNA and protein are proportional to the cell
volume in growing cells. However, models of stochastic gene expression often assume …

Initiation of DNA replication in Escherichia coli is coupled to cell size via the DnaA protein,
whose activity is dependent on its nucleotide-bound state. However, the oscillations in DnaA …

Microbial growth and division are fundamental processes relevant to many areas of life
science. Of particular interest are homeostasis mechanisms, which buffer growth and …

The timing of cell division, and thus cell size in bacteria, is determined in part by the
accumulation dynamics of the protein FtsZ, which forms the septal ring. FtsZ localization …

Which properties of metabolic networks can be derived solely from stoichiometry? Predictive
results have been obtained by flux balance analysis (FBA), by postulating that cells set …

Some phenotypic properties in bacteria exhibit universal statistics, with distributions
collapsing under scaling. The extent and origins of such universality are not well …

Protein concentration in a living cell fluctuates over time due to noise in growth and division
processes. In the high expression regime, variance of the protein concentration in a cell is …