Adipose tissue is necessary to harbor energy. To handle excess energy, adipose tissue
expands by increasing adipocyte size (hypertrophy) and number (hyperplasia). Here, we …

Emerging evidence highlights that dysfunction of adipose tissue contributes to impaired
insulin sensitivity and systemic metabolic deterioration in obese state. Of note, adipocyte …

The volume-regulated anion channel (VRAC) is formed by LRRC8 proteins and is
responsible for the regulatory volume decrease (RVD) after hypotonic cell swelling. Besides …

White adipose tissue (WAT) expansion in obesity occurs through enlargement of preexisting
adipocytes (hypertrophy) and through formation of new adipocytes (adipogenesis) …

SWELL1 (LRRC8A) is the only essential subunit of the Volume Regulated Anion Channel
(VRAC), which regulates cellular volume homeostasis and is activated by hypotonic …

Obesity and its' associated metabolic diseases such as type 2 diabetes and cardiometabolic
disorders are significant health problems confronting many countries. A major driver for …

Adipocytes are specialized cells with pleiotropic roles in physiology and pathology. Several
types of fat cells with distinct metabolic properties coexist in various anatomically defined fat …

Adipose tissue dysfunction is critical to the development of type II diabetes and other
metabolic diseases. While monolayer cell culture has been useful for studying fat biology …

Leucine-rich repeat-containing protein 8 (LRRC8) family members form volume-regulated
anion channels activated by hypoosmotic cell swelling. LRRC8 channels are ubiquitously …

Hypoosmotic conditions activate volume-regulated anion channels in vertebrate cells. These
channels are formed by leucine-rich repeat-containing protein 8 (LRRC8) family members …