Invasive species are increasingly affecting agriculture, food, fisheries, and forestry resources
throughout the world. As a result of global trade, invasive species are often introduced into …

Mosquitoes bring global health problems by transmitting parasites and viruses such as
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …

Aedes aegypti is the principal mosquito vector for many arboviruses that increasingly infect
millions of people every year. With an escalating burden of infections and the relative failure …

There is great interest in being able to spread beneficial traits throughout wild populations in
ways that are self-sustaining. Here, we describe a chromosomal selfish genetic element …

Engineered gene drives are being explored as a new strategy in the fight against vector-
borne diseases due to their potential for rapidly spreading genetic modifications through a …

Invasive rodents are a major cause of environmental damage and biodiversity loss,
particularly on islands. Unlike insects, genetic biocontrol strategies including population …

CRISPR-based gene-drive systems, which copy themselves via gene conversion mediated
by the homology-directed repair (HDR) pathway, have the potential to revolutionize vector …

Engineered gene drives based on a homing mechanism could rapidly spread genetic
alterations through a population. However, such drives face a major obstacle in the form of …

Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

CRISPR-based homing gene drives have sparked both enthusiasm and deep concerns due
to their potential for genetically altering entire species. This raises the question about our …