Thanks to its safety and accessibility, magnetic resonance imaging (MRI) is extensively used
in clinical routine and research field, largely contributing to our understanding of the …

Abstract “The Scaffolding Theory of Aging and Cognition (STAC)”, proposed in 2009, is a
conceptual model of cognitive aging that integrated evidence from structural and functional …

Quantifying the microstructural properties of the human brain's connections is necessary for
understanding normal ageing and disease. Here we examine brain white matter magnetic …

Background The P300 component of the event-related potential is a large positive waveform
that can be extracted from the ongoing electroencephalogram using a two-stimuli oddball …

Abstract Properties of human brain tissue change across the lifespan. Here we model these
changes in the living human brain by combining quantitative magnetic resonance imaging …

Cognition arises as a result of coordinated processing among distributed brain regions and
disruptions to communication within these neural networks can result in cognitive …

Higher order speeded cognitive abilities depend on efficient coordination of activity across
the brain, rendering them vulnerable to age reductions in structural and functional brain …

White matter deterioration is associated with cognitive impairment in healthy aging and
Alzheimer's disease. It is critical to identify interventions that can slow down white matter …

Age-related microstructural differences have been detected using diffusion tensor imaging
(DTI). Although DTI is sensitive to the effects of aging, it is not specific to any underlying …

Alzheimer's disease (AD) has traditionally been regarded as a disease of the gray matter
(GM). However, the advent of diffusion tensor imaging (DTI) has contributed to new …