Imaging approaches to investigate pathophysiological mechanisms of brain disease in zebrafish

L Turrini, L Roschi, G de Vito, FS Pavone… - International Journal of …, 2023 - mdpi.com
Zebrafish has become an essential model organism in modern biomedical research. Owing
to its distinctive features and high grade of genomic homology with humans, it is increasingly …

A single-cell resolution gene expression atlas of the larval zebrafish brain

I Shainer, E Kuehn, E Laurell, M Al Kassar… - Science …, 2023 - science.org
The advent of multimodal brain atlases promises to accelerate progress in neuroscience by
allowing in silico queries of neuron morphology, connectivity, and gene expression. We …

Larval zebrafish as a model for mechanistic discovery in mental health

JXM Tan, RJW Ang, CL Wee - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Animal models are essential for the discovery of mechanisms and treatments for
neuropsychiatric disorders. However, complex mental health disorders such as depression …

[HTML][HTML] Using pERK immunostaining to quantify neuronal activity induced by stress in zebrafish larvae

L Corradi, M Zaupa, S Sawamiphak, A Filosa - STAR protocols, 2022 - Elsevier
The larval zebrafish has emerged as a very useful model organism to study the neuronal
circuits controlling neuroendocrine and behavioral responses to stress. This protocol …

Utility of the Zebrafish Model for Studying Neuronal and Behavioral Disturbances Induced by Embryonic Exposure to Alcohol, Nicotine, and Cannabis

AD Collier, AR Abdulai, SF Leibowitz - Cells, 2023 - mdpi.com
It is estimated that 5% of pregnant women consume drugs of abuse during pregnancy.
Clinical research suggests that intake of drugs during pregnancy, such as alcohol, nicotine …

[HTML][HTML] The preoptic area and dorsal habenula jointly support homeostatic navigation in larval zebrafish

V Palieri, E Paoli, YK Wu, M Haesemeyer, ICG Kadow… - Current Biology, 2024 - cell.com
Animals must maintain physiological processes within an optimal temperature range despite
changes in their environment. Through behavioral assays, whole-brain functional imaging …

Benincasa hispida Alleviates Stress and Anxiety in a Zebrafish (Danio rerio) Model

NK Lakshmanagowda, N Sagar, R Puttasiddaiah… - Life, 2024 - mdpi.com
The Ayurvedic medical system uses fruits of the Benincasa hispida plant to treat mental
diseases, including schizophrenia. The goal of the current study was to assess the aqueous …

Guardian of Excitability: Multifaceted Role of Galanin in Whole Brain Excitability

NN Rieser, M Ronchetti, AL Hotz, SCF Neuhauss - bioRxiv, 2024 - biorxiv.org
Galanin is a neuropeptide, which is critically involved in homeostatic processes like
controlling arousal, sleep, and regulation of stress. This extensive range of functions aligns …

Whole-brain mapping in adult zebrafish and identification of a novel tank test functional connectome

N Rajput, K Parikh, A Squires, KK Fields, M Wong… - …, 2024 - pmc.ncbi.nlm.nih.gov
Identifying general principles of brain function requires the study of structure-function
relationships in a variety of species. Zebrafish have recently gained prominence as a model …

Regulation of Global Neuronal Excitability by Galanin

N Rieser - 2024 - zora.uzh.ch
Galanin is a neuropeptide, which is critically involved in homeostatic processes like
controlling arousal, sleep, and regulation of stress. This extensive range of functions aligns …