RNA drugs and RNA targets for small molecules: principles, progress, and challenges
RNA-based therapies, including RNA molecules as drugs and RNA-targeted small
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …
[HTML][HTML] Influenza virus activation of the interferon system
MJ Killip, E Fodor, RE Randall - Virus research, 2015 - Elsevier
The host interferon (IFN) response represents one of the first barriers that influenza viruses
must surmount in order to establish an infection. Many advances have been made in recent …
must surmount in order to establish an infection. Many advances have been made in recent …
Small molecules targeting viral RNA
T Hermann - Wiley Interdisciplinary Reviews: RNA, 2016 - Wiley Online Library
Highly conserved noncoding RNA (ncRNA) elements in viral genomes and transcripts offer
new opportunities to expand the repertoire of drug targets for the development of …
new opportunities to expand the repertoire of drug targets for the development of …
The influenza virus RNA synthesis machine: advances in its structure and function
P Resa-Infante, N Jorba, R Coloma, J Ortin - RNA biology, 2011 - Taylor & Francis
The influenza A viruses are the causative agents of respiratory disease that occurs as yearly
epidemics and occasional pandemics. These viruses are endemic in wild avian species and …
epidemics and occasional pandemics. These viruses are endemic in wild avian species and …
The influenza A virus genome packaging network—complex, flexible and yet unsolved
C Jakob, R Paul-Stansilaus, M Schwemmle… - Nucleic Acids …, 2022 - academic.oup.com
The genome of influenza A virus (IAV) consists of eight unique viral RNA segments. This
genome organization allows genetic reassortment between co-infecting IAV strains …
genome organization allows genetic reassortment between co-infecting IAV strains …
Orthomyxovirus replication, transcription, and polyadenylation
Efficient in vitro and in vivo systems are now in place to study the role of viral proteins in
replication and/or transcription, the regulation of these processes, polyadenylation of viral …
replication and/or transcription, the regulation of these processes, polyadenylation of viral …
High-resolution NMR structure of an RNA model system: the 14-mer cUUCGg tetraloop hairpin RNA
S Nozinovic, B Fürtig, HRA Jonker… - Nucleic acids …, 2010 - academic.oup.com
We present a high-resolution nuclear magnetic resonance (NMR) solution structure of a 14-
mer RNA hairpin capped by cUUCGg tetraloop. This short and very stable RNA presents an …
mer RNA hairpin capped by cUUCGg tetraloop. This short and very stable RNA presents an …
Influenza A virus panhandle structure is directly involved in RIG-I activation and interferon induction
Retinoic acid-inducible gene I (RIG-I) is an important innate immune sensor that recognizes
viral RNA in the cytoplasm. Its nonself recognition largely depends on the unique RNA …
viral RNA in the cytoplasm. Its nonself recognition largely depends on the unique RNA …
cis-Acting Packaging Signals in the Influenza Virus PB1, PB2, and PA Genomic RNA Segments
Y Liang, Y Hong, TG Parslow - Journal of virology, 2005 - Am Soc Microbiol
The influenza A virus genome consists of eight negative-sense RNA segments. The cis-
acting signals that allow these viral RNA segments (vRNAs) to be packaged into influenza …
acting signals that allow these viral RNA segments (vRNAs) to be packaged into influenza …
Packaging signal of influenza A virus
X Li, M Gu, Q Zheng, R Gao, X Liu - Virology Journal, 2021 - Springer
Influenza A virus (IAV) contains a genome with eight single-stranded, negative-sense RNA
segments that encode 17 proteins. During its assembly, all eight separate viral RNA (vRNA) …
segments that encode 17 proteins. During its assembly, all eight separate viral RNA (vRNA) …