Fundamentals of protein interaction network mapping
Studying protein interaction networks of all proteins in an organism (“interactomes”) remains
one of the major challenges in modern biomedicine. Such information is crucial to …
one of the major challenges in modern biomedicine. Such information is crucial to …
JAK‐STAT core cancer pathway: an integrative cancer interactome analysis
Through a comprehensive review and in silico analysis of reported data on STAT‐linked
diseases, we analysed the communication pathways and interactome of the seven STATs in …
diseases, we analysed the communication pathways and interactome of the seven STATs in …
[HTML][HTML] Information fusion as an integrative cross-cutting enabler to achieve robust, explainable, and trustworthy medical artificial intelligence
Medical artificial intelligence (AI) systems have been remarkably successful, even
outperforming human performance at certain tasks. There is no doubt that AI is important to …
outperforming human performance at certain tasks. There is no doubt that AI is important to …
[HTML][HTML] A physical wiring diagram for the human immune system
The human immune system is composed of a distributed network of cells circulating
throughout the body, which must dynamically form physical associations and communicate …
throughout the body, which must dynamically form physical associations and communicate …
IID 2018 update: context-specific physical protein–protein interactions in human, model organisms and domesticated species
M Kotlyar, C Pastrello, Z Malik… - Nucleic acids research, 2019 - academic.oup.com
Knowing the set of physical protein–protein interactions (PPIs) that occur in a particular
context—a tissue, disease, or other condition—can provide valuable insights into key …
context—a tissue, disease, or other condition—can provide valuable insights into key …
Integrated interactions database: tissue-specific view of the human and model organism interactomes
M Kotlyar, C Pastrello, N Sheahan… - Nucleic acids …, 2016 - academic.oup.com
Abstract IID (Integrated Interactions Database) is the first database providing tissue-specific
protein–protein interactions (PPIs) for model organisms and human. IID covers six species …
protein–protein interactions (PPIs) for model organisms and human. IID covers six species …
IID 2021: towards context-specific protein interaction analyses by increased coverage, enhanced annotation and enrichment analysis
M Kotlyar, C Pastrello, Z Ahmed, J Chee… - Nucleic acids …, 2022 - academic.oup.com
Improved bioassays have significantly increased the rate of identifying new protein-protein
interactions (PPIs), and the number of detected human PPIs has greatly exceeded early …
interactions (PPIs), and the number of detected human PPIs has greatly exceeded early …
[HTML][HTML] Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health
HC Jubb, AP Pandurangan, MA Turner… - Progress in biophysics …, 2017 - Elsevier
Many essential biological processes including cell regulation and signalling are mediated
through the assembly of protein complexes. Changes to protein-protein interaction (PPI) …
through the assembly of protein complexes. Changes to protein-protein interaction (PPI) …
[HTML][HTML] Computational prediction of protein interfaces: A review of data driven methods
Reliably pinpointing which specific amino acid residues form the interface (s) between a
protein and its binding partner (s) is critical for understanding the structural and …
protein and its binding partner (s) is critical for understanding the structural and …
Protein‐protein interaction networks as miners of biological discovery
Protein‐protein interactions (PPIs) form the basis of a myriad of biological pathways and
mechanism, such as the formation of protein complexes or the components of signaling …
mechanism, such as the formation of protein complexes or the components of signaling …