Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

Lipids are a complex and diverse group of molecules with crucial roles in many
physiological processes, as well as in the onset, progression, and maintenance of cancers …

Initially a condition that received limited recognition and whose clinical impact was
controversial, non-alcoholic steatohepatitis (NASH) has become a leading cause of chronic …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Non-alcoholic fatty liver disease (NAFLD) is a series of diseases, involving excessive lipid
deposition in the liver and is often accompanied by obesity, diabetes, dyslipidemia …

Nonalcoholic fatty liver disease consists of a spectrum starting from nonalcoholic fatty liver
disease that may progress to nonalcoholic steatohepatitis (NASH), which can lead to …

Summary The PNPLA3 I148M variant is the major genetic risk factor for all stages of fatty
liver disease, but the underlying pathophysiology remains unclear. We studied the effect of …

Background & Aims The pathogenesis of liver fibrosis requires activation of hepatic stellate
cells (HSCs); once activated, HSCs lose intracellular fatty acids but the role of fatty acid …

Nonalcoholic fatty liver disease (NAFLD) encompasses a disease continuum from simple
steatosis to nonalcoholic steatohepatitis (NASH). However, there are currently no approved …

Worldwide, over 800 million people are affected by kidney disease, yet its pathogenesis
remains elusive, hindering the development of novel therapeutics. In this study, we used …