Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes

S Gurunathan, MH Kang, M Jeyaraj, M Qasim, JH Kim - Cells, 2019 - mdpi.com
Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids,
RNA, and DNA. They are derived from endocytic membranes and can transfer signals to …

Unlocking the power of exosomes for crossing biological barriers in drug delivery

RO Elliott, M He - Pharmaceutics, 2021 - mdpi.com
Since the 2013 Nobel Prize was awarded for the discovery of vesicle trafficking, a subgroup
of nanovesicles called exosomes has been driving the research field to a new regime for …

[HTML][HTML] Exosomes from M1-polarized macrophages enhance paclitaxel antitumor activity by activating macrophages-mediated inflammation

P Wang, H Wang, Q Huang, C Peng, L Yao, H Chen… - Theranostics, 2019 - ncbi.nlm.nih.gov
Objective: Exosomes (Exos) are membrane-encased vesicles derived by nearly all cell types
for intercellular communication and regulation. They also received attention for their use as …

Inflammation in the pathophysiology of neuropathic pain

C Sommer, M Leinders, N Üçeyler - Pain, 2018 - journals.lww.com
2. Methods This is a narrative review based on the authors' research and on that of groups
working in the same area. Given the vast amount of data in the field, it is not possible to …

Immune cells-derived exosomes function as a double-edged sword: role in disease progression and their therapeutic applications

A Hazrati, S Soudi, K Malekpour, M Mahmoudi… - Biomarker …, 2022 - Springer
Exosomes, ranging in size from 30 to 150 nm as identified initially via electron microscopy in
1946, are one of the extracellular vesicles (EVs) produced by many cells and have been the …

Macrophage exosomes resolve atherosclerosis by regulating hematopoiesis and inflammation via MicroRNA cargo

L Bouchareychas, P Duong, S Covarrubias, E Alsop… - Cell reports, 2020 - cell.com
Developing strategies that promote the resolution of vascular inflammation and
atherosclerosis remains a major therapeutic challenge. Here, we show that exosomes …

[HTML][HTML] Exosomes derived from natural killer cells exert therapeutic effect in melanoma

L Zhu, S Kalimuthu, P Gangadaran, JM Oh, HW Lee… - Theranostics, 2017 - ncbi.nlm.nih.gov
Objective: Exosomes are nanovesicles that are released from normal and tumor cells and
are detectable in cell culture supernatant and human biological fluids. Although previous …

Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3β pathway

H Wang, H Sui, Y Zheng, Y Jiang, Y Shi, J Liang… - Nanoscale, 2019 - pubs.rsc.org
Alzheimer's disease (AD) is the progressive development of fatal neurodegenerative
diseases. Owing to the unclearness of the pathogenesis of AD and the failure of the drug to …

M2 macrophage-derived exosomes carry microRNA-148a to alleviate myocardial ischemia/reperfusion injury via inhibiting TXNIP and the TLR4/NF-κB/NLRP3 …

Y Dai, S Wang, S Chang, D Ren, S Shali, C Li… - Journal of molecular and …, 2020 - Elsevier
Background Reperfusion may cause injuries to the myocardium in ischemia situation.
Emerging studies suggest that exosomes may serve as key mediators in myocardial …

Exosomes as biomarkers and therapeutic delivery for autoimmune diseases: opportunities and challenges

Y Fang, J Ni, YS Wang, Y Zhao, LQ Jiang, C Chen… - Autoimmunity …, 2023 - Elsevier
Exosomes are spherical lipid bilayer vesicles composed of lipids, proteins and nucleic acids
that deliver signaling molecules through a vesicular transport system to regulate the function …