Tight regulation of inflammation is very important to guarantee a balanced immune response
without developing chronic inflammation. One of the major mediators of the resolution of …

In response to stress signal, nuclear factor‐erythroid 2‐related factor 2 (Nrf2) induces the
expression of target genes involved in antioxidant defense and detoxification. Nrf2 activity is …

The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is …

The concept of macroautophagy was established in 1963, soon after the discovery of
lysosomes in rat liver. Over the 50 years since, studies of liver autophagy have produced …

p62/SQSTM 1 is a stress‐inducible cellular protein that is conserved among metazoans but
not in plants and fungi. p62/SQSTM 1 has multiple domains that mediate its interactions with …

Most neurodegenerative diseases that afflict humans are associated with the
intracytoplasmic deposition of aggregate-prone proteins in neurons and with mitochondrial …

Cellular homeostasis requires the swift and specific removal of damaged material. Selective
autophagy represents a major pathway for the degradation of such cargo material. This is …

Ubiquitination is a widespread post-translational modification that controls multiple steps in
autophagy, a major lysosome-mediated intracellular degradation pathway. A variety of …

Selective autophagy ensures recognition and removal of various cytosolic cargos. Hence,
aggregated proteins, damaged organelles, or pathogens are enclosed into the double …

The removal of misfolded, ubiquitinated proteins is an essential part of the protein quality
control. The ubiquitin‐proteasome system (UPS) and autophagy are two interconnected …