Electrical activity in neurons requires a seamless functional coupling between
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …

Recent years have witnessed a steep increase in studies on the diverse roles of neuronal
cation-chloride cotransporters (CCCs). The versatility of CCC gene transcription …

With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid
(GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride …

The K–Cl cotransporter KCC2 establishes the low intraneuronal Cl–levels required for the
hyperpolarizing inhibitory postsynaptic potentials mediated by ionotropic γ-aminobutyric …

Deficits in GABAergic inhibition result in the abnormal neuronal activation and
synchronization that underlies seizures. However, the molecular mechanisms responsible …

The potassium chloride cotransporter KCC2 plays a major role in the maintenance of
transmembrane chloride potential in mature neurons; thus KCC2 activity is critical for …

GABAA receptor-mediated inhibition depends on the maintenance of intracellular Cl−
concentration ([Cl−] in) at low levels. In neurons in the developing CNS,[Cl−] in is elevated, E …

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the methyl
CpG binding protein 2 (MECP2) gene. There are currently no approved treatments for RTT …

Central neurons respond to synaptic inputs from other neurons by generating synaptic
potentials. Once the summated synaptic potentials reach threshold for action potential firing …