Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

Several lines of recent evidence indicate that the amyloid precursor protein-derived C-
terminal fragments (APP-CTFs) could correspond to an etiological trigger of Alzheimer's …

Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Although an
accumulation of brain amyloid-β (Aβ) peptide and hyperphosphorylated tau protein have …

In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid
precursor protein (APP) is cleaved by β‐secretase to generate a 99‐aa C‐terminal fragment …

In the last few years, increased emphasis has been devoted to understanding the
contribution of mitochondria-associated endoplasmic reticulum (ER) membranes (MAM) to …

Background Alzheimer's disease (AD) exhibits mitochondrial dysfunctions associated with
dysregulated metabolism, brain inflammation, synaptic loss, and neuronal cell death. As a …

The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to
the Alzheimer's disease (AD) field. Decades of research define how APP is altered to form …

Synaptic pathology and mitochondrial oxidative damage are early events in Alzheimer's
disease (AD) progression. Loss of synapses and synaptic damage are the best correlates of …

The purpose of our study was to determine the relationship between voltage-dependent
anion channel 1 protein (VDAC1) and amyloid beta (Aβ) and phosphorylated tau in …