Delta-like non-canonical Notch ligand 1 (DLK1) is a cleavable single-pass transmembrane
protein and a member of the Notch/Delta/Serrate family. It is paternally expressed and …

Simple Summary As one of most malignant tumors in brain, glioblastoma (GBM) is lack of
effective treatment and the prognosis of GBM patients is still very poor despite accumulated …

Glioblastoma is an aggressive form of brain cancer with well-established patterns of intra-
tumoral heterogeneity implicated in treatment resistance and progression. While regional …

Background Glioma is a common type of malignant brain tumor with a high mortality and
relapse rate. The endosomal sorting complex required for transport (ESCRT) has been …

Previous studies have suggested that hypoxic responses are regulated by hypoxia-inducible
factors (HIFs), which in turn promote the malignant progression of glioblastoma (GBM) by …

DLK1 is a maternally imprinted, paternally expressed gene coding for the transmembrane
protein Delta-like homologue 1 (DLK1), a non-canonical NOTCH ligand with well-described …

The human brain represents one of the most complex biological structures with significant
spatiotemporal molecular plasticity occurring through early development, learning, aging …

Background Delta‐like homologue 1 (DLK1), a transmembrane protein, is highly expressed
in hepatocellular carcinoma (HCC). We explored whether DLK1‐directed chimeric antigen …

Glioma is the most common primary brain tumor, and its prognosis is poor. Glioma cells are
highly invasive to the brain parenchyma. It is difficult to achieve complete resection due to …

Gliomas are central nervous system tumors originating from glial cells, whose incidence and
mortality rise in coming years. The current treatment of gliomas is surgery combined with …