Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

E Connell, G Le Gall, MG Pontifex, S Sami… - Molecular …, 2022 - Springer
A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

Metabolic profiling and metabolites fingerprints in human hypertension: discovery and potential

JO Onuh, H Qiu - Metabolites, 2021 - mdpi.com
Early detection of pathogenesis through biomarkers holds the key to controlling
hypertension and preventing cardiovascular complications. Metabolomics profiling acts as a …

Physiopathological mechanisms involved in the development of hypertension associated with gut dysbiosis and the effect of nutritional/pharmacological interventions

VMM Giménez, NLR Mikusic, HJ Lee… - Biochemical …, 2022 - Elsevier
The gut microbiota dysbiosis represents a triggering factor for cardiovascular diseases,
including hypertension. In addition to the harmful impact caused by hypertension on different …

Human blood bacteriome: Eubiotic and dysbiotic states in health and diseases

K Suparan, S Sriwichaiin, N Chattipakorn… - Cells, 2022 - mdpi.com
The human gut microbiome is acknowledged as being associated with homeostasis and the
pathogenesis of several diseases. Conventional culture techniques are limited in that they …

Comprehensive analysis of metabolic changes in spontaneously hypertensive rats

Y Li, D Xie, L Li, P Jiang - Clinical and Experimental Hypertension, 2023 - Taylor & Francis
Objectives Hypertension is a chronic disease with multiple causative factors that involve
metabolic disturbances and can cause various complications. However, the metabolic …

Global interventions in hypertension: new and emerging concepts

KC Ferdinand, TK Reddy, TN Vo - Current Opinion in Cardiology, 2021 - journals.lww.com
Global interventions in hypertension: new and emerging conce... : Current Opinion in
Cardiology Global interventions in hypertension: new and emerging concepts : Current Opinion …

APOE alleles modulate associations of plasma metabolites with variants from multiple genes on chromosome 19q13.3

A Nazarian, E Loiko, HN Yassine, CE Finch… - Frontiers in Aging …, 2022 - frontiersin.org
The APOE ε2, ε3, and ε4 alleles differentially impact various complex diseases and traits. We
examined whether these alleles modulated associations of 94 single-nucleotide …

Research progress on the correlation between sacubitril-valsartan and cognitive function in hypertensive patients

J Ma, R Li - Highlights in Science, Engineering and Technology, 2022 - drpress.org
Sacubitril-valsartan can exert antihypertensive effects by blocking the effect of angiotensin
Ⅱ and inhibiting the activity of enkephalinase. As a currently common antihypertensive drug …

[PDF][PDF] Metabolic Profiling and Metabolites Fingerprints in Human Hypertension: Discovery and Potential. Metabolites 2021, 11, 687

JO Onuh, H Qiu - 2021 - researchgate.net
Early detection of pathogenesis through biomarkers holds the key to controlling
hypertension and preventing cardiovascular complications. Metabolomics profiling acts as a …