The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …

Significance: Mitochondria play a critical role in the physiology of the heart by controlling
cardiac metabolism, function, and remodeling. Accumulation of fragmented and damaged …

Environmental factors are the largest contributors to cardiovascular disease. Here we show
that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated …

Piezo1 is a mechanosensitive cation channel with widespread physiological importance;
however, its role in the heart is poorly understood. Cardiac fibroblasts help preserve …

Tissue engineering has enabled the development of advanced and physiologically relevant
models of cardiovascular diseases, with advantages over conventional 2D in vitro assays …

Cell fate is correlated to mechanotransduction, in which forces transmitted by the
cytoskeleton filaments alter the nuclear shape, affecting transcription factor import/export …

Mechanobiology-on-a-chip is a growing field focusing on how mechanical inputs modulate
physico-chemical output in microphysiological systems. It is well known that biomechanical …

Bioprinting holds great promise toward engineering functional cardiac tissue constructs for
regenerative medicine and as drug test models. However, it is highly limited by the choice of …

Replication of physiological oxygen levels is fundamental for modeling human physiology
and pathology in in vitro models. Environmental oxygen levels, applied in most in vitro …

Cardiac tissue is characterized by being dynamic and contractile, imparting the important
role of biomechanical cues in the regulation of normal physiological activity or pathological …