Point‐of‐care testing in haemostasis

DJ Perry, DA Fitzmaurice, S Kitchen… - British Journal of …, 2010 - Wiley Online Library
Point‐of‐care testing (POCT) in haematology has seen a significant increase in both the
spectrum of tests available and the number of tests performed annually. POCT is frequently …

Tranexamic acid in trauma: how should we use it?

LM Napolitano, MJ Cohen, BA Cotton… - Journal of Trauma …, 2013 - journals.lww.com
The CRASH-2 trial results have prompted trauma centers to contemplate whether
tranexamic acid (TXA) should be added to their armamentarium for the treatment of bleeding …

Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration

BA Cotton, JA Harvin, V Kostousouv… - Journal of Trauma …, 2012 - journals.lww.com
BACKGROUND Hyperfibrinolysis (HF) has been reported to occur in a range of 2% to 34%
of trauma patients. Using rapid thromboelastography (r-TEG), we hypothesized that HF is (1) …

Thrombelastography and tromboelastometry in assessing coagulopathy in trauma

PI Johansson, T Stissing, L Bochsen… - Scandinavian journal of …, 2009 - Springer
Death due to trauma is the leading cause of lost life years worldwide, with haemorrhage
being responsible for 30-40% of trauma mortality and accounting for almost 50% of the …

Thrombelastography (TEG®): practical considerations on its clinical use in trauma resuscitation

LT da Luz, B Nascimento, S Rizoli - Scandinavian journal of trauma …, 2013 - Springer
Background Thrombelastography is a laboratorial test that measures viscoelastic changes of
the entire clotting process. There is growing interest in its clinical use in trauma resuscitation …

The effect of TiO2 nanotubes in the enhancement of blood clotting for the control of hemorrhage

SC Roy, M Paulose, CA Grimes - Biomaterials, 2007 - Elsevier
The main biological purpose of blood coagulation is formation of an obstacle to prevent
blood loss of hydraulic strength sufficient to withstand the blood pressure. The ability to …

Effects of a single bout of walking exercise on blood coagulation parameters in obese women

M Lamprecht, H Moussalli, G Ledinski… - Journal of applied …, 2013 - journals.physiology.org
Obesity is associated with increased prevalence of thromboembolic events. We aimed to
investigate whether obese women might benefit from vigorous aerobic exercise. Forty-two …

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin (ogen)

DB Kell, E Pretorius - Integrative Biology, 2015 - academic.oup.com
Although the two phenomena are usually studied separately, we summarise a considerable
body of literature to the effect that a great many diseases involve (or are accompanied by) …

Validation of a modified thromboelastometry approach to detect changes in fibrinolytic activity

GJ Kuiper, MCF Kleinegris, R van Oerle… - Thrombosis journal, 2016 - Springer
Background Thus far, validated whole blood assays used in in vitro fibrinolysis experiments
using thromboelastometry (ROTEM) are lacking or have yet to be tested in humans. The …

Factor XIII and tranexamic acid but not recombinant Factor VIIa attenuate tissue plasminogen activator–induced hyperfibrinolysis in human whole blood

D Dirkmann, K Görlinger, C Gisbertz… - Anesthesia & …, 2012 - journals.lww.com
BACKGROUND: Hyperfibrinolysis is a pathological state that often results in depletion of
coagulation factors and platelets and can contribute to bleeding. Factor XIII (FXIII) and …