The so-called 'replicability crisis' has sparked methodological discussions in many areas of
science in general, and in psychology in particular. This has led to recent endeavours to …

The bed nucleus of the stria terminalis (BNST) is a center of integration for limbic information
and valence monitoring. The BNST, sometimes referred to as the extended amygdala, is …

Uncertainty about a possible future threat disrupts our ability to avoid it or to mitigate its
negative impact and thus results in anxiety. Here, we focus the broad literature on the …

Objective: Although anxiety can be an adaptive response to unpredictable threats,
pathological anxiety disorders occur when symptoms adversely affect daily life. Whether or …

It has been argued that emotion, pain and cognitive control are functionally segregated in
distinct subdivisions of the cingulate cortex. However, recent observations encourage a …

The consequences of chronic stress on brain structure and function are far reaching.
Whereas stress can produce short-term adaptive changes in the brain, chronic stress leads …

Anxiety disorders impose a staggering burden on public health, underscoring the need to
develop a deeper understanding of the distributed neural circuits underlying extreme fear …

The central extended amygdala is an evolutionarily conserved set of interconnected brain
regions that play an important role in threat processing to promote survival. Two core …

Anxiety is an adaptive response that promotes harm avoidance, but at the same time
excessive anxiety constitutes the most common psychiatric complaint. Moreover, current …

Early‐life stress confers profound and lasting risk for developing cognitive, social, emotional,
and physical health problems. The effects of stress on the developing brain contribute to this …