The role of xenobiotic-metabolizing enzymes in anthelmintic deactivation and resistance in helminths

P Matoušková, I Vokřál, J Lamka, L Skálová - Trends in parasitology, 2016 - cell.com
Xenobiotic-metabolizing enzymes (XMEs) modulate the biological activity and behavior of
many drugs, including anthelmintics. The effects of anthelmintics can often be abolished by …

Evolutionary adaptations of parasitic flatworms to different oxygen tensions

JJ Martínez-González, A Guevara-Flores… - Antioxidants, 2022 - mdpi.com
During the evolution of the Earth, the increase in the atmospheric concentration of oxygen
gave rise to the development of organisms with aerobic metabolism, which utilized this …

Evidence of Immune Modulators in the Secretome of the Equine Tapeworm Anoplocephala perfoliata

B Wititkornkul, BJ Hulme, JJ Tomes, NR Allen… - Pathogens, 2021 - mdpi.com
Anoplocephala perfoliata is a neglected gastro-intestinal tapeworm, commonly infecting
horses worldwide. Molecular investigation of A. perfoliata is hampered by a lack of tools to …

Unraveling oxidative stress response in the cestode parasite Echinococcus granulosus

M Cancela, JA Paes, H Moura, JR Barr, A Zaha… - Scientific Reports, 2019 - nature.com
Cystic hydatid disease (CHD) is a worldwide neglected zoonotic disease caused by
Echinococcus granulosus. The parasite is well adapted to its host by producing protective …

Molecular characteristics of glutathione transferase gene family in a neglect medical Spirometra tapeworm

WQ Chen, SS Liu, C Cheng, J Cui, ZQ Wang… - Frontiers in Veterinary …, 2022 - frontiersin.org
The Spirometra mansoni is a neglect medical tapeworm, its plerocercoid larvae can
parasitize in humans and animals, causing sparganosis. In this study, 17 new members of …

Biochemical characterization and gene structure analysis of the 24‐kDa glutathione transferase sigma from Taenia solium

R Miranda‐Blancas, O Rodríguez‐Lima… - FEBS Open …, 2024 - Wiley Online Library
Taenia solium can cause human taeniasis and/or cysticercosis. The latter can in some
instances cause human neurocysticercosis which is considered a priority in disease‐control …

Identification of Omega-class glutathione transferases in helminths of the Taeniidae family

S Miles, G Mourglia-Ettlin, V Fernández - Molecular and Biochemical …, 2023 - Elsevier
Glutathione transferase enzymes (GSTs) are believed to be a major detoxification system in
helminth parasites and have been associated with immunomodulation of the host response …

Immunization with a Mu-class glutathione transferase from Echinococcus granulosus induces efficient antibody responses and confers long-term protection against …

P Arbildi, AC Muniz-Lagos, E Fernández, R Giorgi… - Microbes and …, 2024 - Elsevier
Cystic echinococcosis, a zoonosis caused by cestodes belonging to the Echinococcus
granulosus sensu lato (sl) genetic complex, affects humans and diverse livestock species …

Expanding the family of Mu-class glutathione transferases in the cestode parasite Echinococcus granulosus sensu lato

S Miles, G Mourglia-Ettlin, V Fernández - Gene, 2022 - Elsevier
Glutathione transferases (GSTs) perform catalytic and non-catalytic activities, mostly
involved in stress-response and cell detoxification. Helminth parasites express several GSTs …

A dominance of Mu class glutathione transferases within the equine tapeworm Anoplocephala perfoliata

HM Northcote, B Wititkornkul, DJ Cutress, ND Allen… - Parasitology, 2024 - cambridge.org
The most common equine tapeworm, Anoplocephala perfoliata, has often been neglected
amongst molecular investigations and has been faced with limited treatment options …