Treatment of low-risk gestational trophoblastic neoplasia

MC Winter - Best Practice & Research Clinical Obstetrics & …, 2021 - Elsevier
Low-risk gestational trophoblastic neoplasia (GTN), defined as FIGO/WHO score 0–6, is
highly curable with an overall survival rate, which is approximately 100%. For most low-risk …

Current chemotherapeutic options for the treatment of gestational trophoblastic disease

A Braga, G Paiva, CJ Cattai, KM Elias… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Gestational trophoblastic neoplasia (GTN) is a rare tumor that arises from
trophoblastic tissues with high remission rates after chemotherapy treatment. GTN can …

Perinatal outcomes of first pregnancy after chemotherapy for gestational trophoblastic neoplasia: a systematic review of observational studies and meta-analysis

JM Madi, MP Paganella, IE Litvin, M Viggiano… - American Journal of …, 2022 - Elsevier
Objective To assess perinatal outcomes of first pregnancy after remission from gestational
trophoblastic neoplasia and the impact of the time between the end of chemotherapy and …

The efficacy and safety of first-line single-agent chemotherapy regimens in low-risk gestational trophoblastic neoplasia: a network meta-analysis

J Li, S Li, H Yu, J Wang, C Xu, X Lu - Gynecologic Oncology, 2018 - Elsevier
Objective There is no consensus regarding what should be the optimal single-agent
regimen in low-risk gestational trophoblastic neoplasia (LRGTN). we performed this network …

Immunotherapy in the treatment of chemoresistant gestational trophoblastic neoplasia-systematic review with a presentation of the first 4 Brazilian cases

A Braga, E Balthar, LCS Souza, M Samora, M Rech… - Clinics, 2023 - SciELO Brasil
Objective To evaluate the efficacy of immunotherapy for GTN treatment after methotrexate-
resistance or in cases of multiresistant disease, through a systematic review, as well as to …

Direct comparisons of efficacy and safety between actinomycin-D and methotrexate in women with low-risk gestational trophoblastic neoplasia: a meta-analysis of …

J Hao, W Zhou, M Zhang, H Yu, T Zhang, R An, Y Xue - BMC cancer, 2021 - Springer
Abstract Background Actinomycin-D (Act-D) and Methotrexate (MTX) are both effective first-
line agents for low-risk gestational trophoblastic neoplasia (LRGTN) with no consensus …

Can carboplatin or etoposide replace actinomycin-d for second-line treatment of methotrexate resistant low-risk gestational trophoblastic neoplasia?

PAR Mora, SY Sun, GC Velarde, J Rezende Filho… - Gynecologic …, 2019 - Elsevier
Objective To evaluate the impact of periodic shortage of actinomycin-d (Act-d) in the
treatment of Brazilian patients with low-risk gestational trophoblastic neoplasia (GTN) after …

Initial Diagnosis and Treatment of Low-Risk Gestational Trophoblastic Neoplasia

S Alimena, KM Elias, NS Horowitz… - Hematology …, 2024 - hemonc.theclinics.com
Gestational trophoblastic neoplasia (GTN) is a rare form of cancer with excellent cure rates,
in excess of 90% across all stages. 1–4 In large part, this is due to the high sensitivity of …

Does methotrexate (MTX) dosing in a 8-day MTX/FA regimen for the treatment of low-risk gestational trophoblastic neoplasia affect outcomes? The MITO-9 study

G Mangili, R Cioffi, S Danese, L Frigerio… - Gynecologic …, 2018 - Elsevier
Objective To compare clinical outcomes of patients diagnosed with low-risk gestational
trophoblastic neoplasia (GTN) receiving intramuscular methotrexate 50 mg total dose/day …

Influence of COVID‐19 pandemic on molar pregnancy and postmolar gestational trophoblastic neoplasia: An observational study

V Campos, G Paiva, L Padron, F Freitas… - … Journal of Obstetrics …, 2023 - Wiley Online Library
Objective To assess whether the incidence and aggressiveness of molar pregnancy (MP)
and postmolar gestational trophoblastic neoplasia (GTN) changed during the COVID‐19 …