Exosomal delivery of therapeutic modulators through the blood–brain barrier; promise and pitfalls
M Heidarzadeh, Y Gürsoy-Özdemir, M Kaya… - Cell & Bioscience, 2021 - Springer
Nowadays, a large population around the world, especially the elderly, suffers from
neurological inflammatory and degenerative disorders/diseases. Current drug delivery …
neurological inflammatory and degenerative disorders/diseases. Current drug delivery …
Cardiovascular protective effect of black pepper (Piper nigrum L.) and its major bioactive constituent piperine
Abstract Background Cardiovascular diseases (CVDs) are the leading cause of death
worldwide. Black pepper, the fruits of Piper nigrum L., is well known as “the king of spices” …
worldwide. Black pepper, the fruits of Piper nigrum L., is well known as “the king of spices” …
GSH/APE1 cascade-activated nanoplatform for imaging therapy resistance dynamics and enzyme-mediated adaptive ferroptosis
R Yue, M Zhou, X Li, L Xu, C Lu, Z Dong, L Lei, H Liu… - ACS …, 2023 - ACS Publications
Ferroptosis, as a type of programmed cell death process, enables effective damage to
various cancer cells. However, we discovered that persistent oxidative stress during …
various cancer cells. However, we discovered that persistent oxidative stress during …
Atrial cardiomyopathy revisited—evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart …
A Goette, D Corradi, D Dobrev, L Aguinaga… - Europace, 2024 - academic.oup.com
Aims The concept of “atrial cardiomyopathy”(AtCM) had been percolating through the
literature since its first mention in 1972. Since then, publications using the term were …
literature since its first mention in 1972. Since then, publications using the term were …
Salt Sensitivity of Blood Pressure in Blacks and Women: A Role of Inflammation, Oxidative Stress, and Epithelial Na+ Channel
Significance: Salt sensitivity of blood pressure (SSBP) is an independent risk factor for
mortality and morbidity due to cardiovascular disease, and disproportionately affects blacks …
mortality and morbidity due to cardiovascular disease, and disproportionately affects blacks …
Investigating the relationship between job stress, workload and oxidative stress in nurses
J Biganeh, A Ashtarinezhad… - International Journal …, 2022 - Taylor & Francis
Objectives. Occupational stress and workload are common risk factors among nurses that
increase absenteeism, reduce the quality and quantity of patient care, increase care costs …
increase absenteeism, reduce the quality and quantity of patient care, increase care costs …
A promising antifibrotic drug, pyridoxamine attenuates thioacetamide-induced liver fibrosis by combating oxidative stress, advanced glycation end products, and …
Liver fibrosis is a common chronic hepatic disease. This study was done to examine the
effect of pyridoxamine against thioacetamide-induced hepatic fibrosis. Animals were divided …
effect of pyridoxamine against thioacetamide-induced hepatic fibrosis. Animals were divided …
LNK/SH2B3 loss of function increases susceptibility to murine and human atrial fibrillation
MB Murphy, Z Yang, T Subati… - Cardiovascular …, 2024 - academic.oup.com
Aims The lymphocyte adaptor protein (LNK) is a negative regulator of cytokine and growth
factor signalling. The rs3184504 variant in SH2B3 reduces LNK function and is linked to …
factor signalling. The rs3184504 variant in SH2B3 reduces LNK function and is linked to …
[HTML][HTML] CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β‑amyloid metabolism‑associated enzymes
H Jiang, F Niu, Y Zheng, Y Xu - Molecular Medicine …, 2021 - spandidos-publications.com
Alzheimer's disease (AD) is the most common form of dementia that is primarily
characterized by progressive cognitive deficits. The toxicity of amyloid β‑protein (Aβ) serves …
characterized by progressive cognitive deficits. The toxicity of amyloid β‑protein (Aβ) serves …
Understanding myeloperoxidase-induced damage to HDL structure and function in the vessel wall: implications for HDL-based therapies
Atherosclerosis is a disease of increased oxidative stress characterized by protein and lipid
modifications in the vessel wall. One important oxidative pathway involves reactive …
modifications in the vessel wall. One important oxidative pathway involves reactive …