Exosomal delivery of therapeutic modulators through the blood–brain barrier; promise and pitfalls

M Heidarzadeh, Y Gürsoy-Özdemir, M Kaya… - Cell & Bioscience, 2021 - Springer
Nowadays, a large population around the world, especially the elderly, suffers from
neurological inflammatory and degenerative disorders/diseases. Current drug delivery …

Cardiovascular protective effect of black pepper (Piper nigrum L.) and its major bioactive constituent piperine

D Wang, L Zhang, J Huang, K Himabindu… - Trends in Food Science …, 2021 - Elsevier
Abstract Background Cardiovascular diseases (CVDs) are the leading cause of death
worldwide. Black pepper, the fruits of Piper nigrum L., is well known as “the king of spices” …

GSH/APE1 cascade-activated nanoplatform for imaging therapy resistance dynamics and enzyme-mediated adaptive ferroptosis

R Yue, M Zhou, X Li, L Xu, C Lu, Z Dong, L Lei, H Liu… - ACS …, 2023 - ACS Publications
Ferroptosis, as a type of programmed cell death process, enables effective damage to
various cancer cells. However, we discovered that persistent oxidative stress during …

Atrial cardiomyopathy revisited—evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart …

A Goette, D Corradi, D Dobrev, L Aguinaga… - Europace, 2024 - academic.oup.com
Aims The concept of “atrial cardiomyopathy”(AtCM) had been percolating through the
literature since its first mention in 1972. Since then, publications using the term were …

Salt Sensitivity of Blood Pressure in Blacks and Women: A Role of Inflammation, Oxidative Stress, and Epithelial Na+ Channel

M Sahinoz, F Elijovich, LA Ertuglu… - Antioxidants & Redox …, 2021 - liebertpub.com
Significance: Salt sensitivity of blood pressure (SSBP) is an independent risk factor for
mortality and morbidity due to cardiovascular disease, and disproportionately affects blacks …

Investigating the relationship between job stress, workload and oxidative stress in nurses

J Biganeh, A Ashtarinezhad… - International Journal …, 2022 - Taylor & Francis
Objectives. Occupational stress and workload are common risk factors among nurses that
increase absenteeism, reduce the quality and quantity of patient care, increase care costs …

A promising antifibrotic drug, pyridoxamine attenuates thioacetamide-induced liver fibrosis by combating oxidative stress, advanced glycation end products, and …

AR Alshanwani, H Hagar, S Shaheen… - European Journal of …, 2022 - Elsevier
Liver fibrosis is a common chronic hepatic disease. This study was done to examine the
effect of pyridoxamine against thioacetamide-induced hepatic fibrosis. Animals were divided …

LNK/SH2B3 loss of function increases susceptibility to murine and human atrial fibrillation

MB Murphy, Z Yang, T Subati… - Cardiovascular …, 2024 - academic.oup.com
Aims The lymphocyte adaptor protein (LNK) is a negative regulator of cytokine and growth
factor signalling. The rs3184504 variant in SH2B3 reduces LNK function and is linked to …

[HTML][HTML] CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β‑amyloid metabolism‑associated enzymes

H Jiang, F Niu, Y Zheng, Y Xu - Molecular Medicine …, 2021 - spandidos-publications.com
Alzheimer's disease (AD) is the most common form of dementia that is primarily
characterized by progressive cognitive deficits. The toxicity of amyloid β‑protein (Aβ) serves …

Understanding myeloperoxidase-induced damage to HDL structure and function in the vessel wall: implications for HDL-based therapies

G Marsche, JT Stadler, J Kargl, M Holzer - Antioxidants, 2022 - mdpi.com
Atherosclerosis is a disease of increased oxidative stress characterized by protein and lipid
modifications in the vessel wall. One important oxidative pathway involves reactive …