State of the art in selection of variables and functional forms in multivariable analysis—outstanding issues

W Sauerbrei, A Perperoglou, M Schmid… - … and prognostic research, 2020 - Springer
Background How to select variables and identify functional forms for continuous variables is
a key concern when creating a multivariable model. Ad hoc 'traditional'approaches to …

Review, evaluation, and discussion of the challenges of missing value imputation for mass spectrometry-based label-free global proteomics

BJM Webb-Robertson, HK Wiberg… - Journal of proteome …, 2015 - ACS Publications
In this review, we apply selected imputation strategies to label-free liquid chromatography–
mass spectrometry (LC–MS) proteomics datasets to evaluate the accuracy with respect to …

[HTML][HTML] Mortality risk profiling of Staphylococcus aureus bacteremia by multi-omic serum analysis reveals early predictive and pathogenic signatures

JM Wozniak, RH Mills, J Olson, JR Caldera… - Cell, 2020 - cell.com
Staphylococcus aureus bacteremia (SaB) causes significant disease in humans, carrying
mortality rates of∼ 25%. The ability to rapidly predict SaB patient responses and guide …

Technical aspects and inter-laboratory variability in native peptide profiling: The CE–MS experience

H Mischak, A Vlahou, JPA Ioannidis - Clinical biochemistry, 2013 - Elsevier
Mass spectrometry platforms have attracted a lot of interest in the last 2 decades as profiling
tools for native peptides and proteins with clinical potential. However, limitations associated …

Peptidomics and proteomics based on CE‐MS as a robust tool in clinical application: The past, the present, and the future

A Latosinska, J Siwy, H Mischak, M Frantzi - Electrophoresis, 2019 - Wiley Online Library
Capillary electrophoresis combined with mass spectrometry (CE‐MS) has been used for
several years for the investigation of proteins and peptides as biomarkers for diagnosis and …

Biomarker discovery in mass spectrometry‐based urinary proteomics

S Thomas, L Hao, WA Ricke, L Li - PROTEOMICS–Clinical …, 2016 - Wiley Online Library
Urinary proteomics has become one of the most attractive topics in disease biomarker
discovery. MS‐based proteomic analysis has advanced continuously and emerged as a …

How (not) to generate a highly predictive biomarker panel using machine learning

H Desaire - Journal of proteome research, 2022 - ACS Publications
This review “teaches” researchers how to make their lackluster proteomics data look really
impressive, by applying an inappropriate but pervasive strategy that selects features in a …

Urinary peptides in heart failure: a link to molecular pathophysiology

T He, M Mischak, AL Clark, RT Campbell… - European Journal of …, 2021 - Wiley Online Library
Aims Heart failure (HF) is a major public health concern worldwide. The diversity of HF
makes it challenging to decipher the underlying complex pathological processes using …

Proteomic biomarkers in kidney disease: issues in development and implementation

H Mischak, C Delles, A Vlahou… - Nature Reviews …, 2015 - nature.com
Proteomic biomarkers offer the hope of improving the management of patients with kidney
diseases by enabling more accurate and earlier detection of renal pathology than is …

Reproducibility evaluation of urinary peptide detection using CE-MS

E Mavrogeorgis, H Mischak, A Latosinska, J Siwy… - Molecules, 2021 - mdpi.com
In recent years, capillary electrophoresis coupled to mass spectrometry (CE-MS) has been
increasingly applied in clinical research especially in the context of chronic and age …