State of the art in selection of variables and functional forms in multivariable analysis—outstanding issues
W Sauerbrei, A Perperoglou, M Schmid… - … and prognostic research, 2020 - Springer
Background How to select variables and identify functional forms for continuous variables is
a key concern when creating a multivariable model. Ad hoc 'traditional'approaches to …
a key concern when creating a multivariable model. Ad hoc 'traditional'approaches to …
Review, evaluation, and discussion of the challenges of missing value imputation for mass spectrometry-based label-free global proteomics
BJM Webb-Robertson, HK Wiberg… - Journal of proteome …, 2015 - ACS Publications
In this review, we apply selected imputation strategies to label-free liquid chromatography–
mass spectrometry (LC–MS) proteomics datasets to evaluate the accuracy with respect to …
mass spectrometry (LC–MS) proteomics datasets to evaluate the accuracy with respect to …
[HTML][HTML] Mortality risk profiling of Staphylococcus aureus bacteremia by multi-omic serum analysis reveals early predictive and pathogenic signatures
Staphylococcus aureus bacteremia (SaB) causes significant disease in humans, carrying
mortality rates of∼ 25%. The ability to rapidly predict SaB patient responses and guide …
mortality rates of∼ 25%. The ability to rapidly predict SaB patient responses and guide …
Technical aspects and inter-laboratory variability in native peptide profiling: The CE–MS experience
H Mischak, A Vlahou, JPA Ioannidis - Clinical biochemistry, 2013 - Elsevier
Mass spectrometry platforms have attracted a lot of interest in the last 2 decades as profiling
tools for native peptides and proteins with clinical potential. However, limitations associated …
tools for native peptides and proteins with clinical potential. However, limitations associated …
Peptidomics and proteomics based on CE‐MS as a robust tool in clinical application: The past, the present, and the future
Capillary electrophoresis combined with mass spectrometry (CE‐MS) has been used for
several years for the investigation of proteins and peptides as biomarkers for diagnosis and …
several years for the investigation of proteins and peptides as biomarkers for diagnosis and …
Biomarker discovery in mass spectrometry‐based urinary proteomics
Urinary proteomics has become one of the most attractive topics in disease biomarker
discovery. MS‐based proteomic analysis has advanced continuously and emerged as a …
discovery. MS‐based proteomic analysis has advanced continuously and emerged as a …
How (not) to generate a highly predictive biomarker panel using machine learning
H Desaire - Journal of proteome research, 2022 - ACS Publications
This review “teaches” researchers how to make their lackluster proteomics data look really
impressive, by applying an inappropriate but pervasive strategy that selects features in a …
impressive, by applying an inappropriate but pervasive strategy that selects features in a …
Urinary peptides in heart failure: a link to molecular pathophysiology
T He, M Mischak, AL Clark, RT Campbell… - European Journal of …, 2021 - Wiley Online Library
Aims Heart failure (HF) is a major public health concern worldwide. The diversity of HF
makes it challenging to decipher the underlying complex pathological processes using …
makes it challenging to decipher the underlying complex pathological processes using …
Proteomic biomarkers in kidney disease: issues in development and implementation
Proteomic biomarkers offer the hope of improving the management of patients with kidney
diseases by enabling more accurate and earlier detection of renal pathology than is …
diseases by enabling more accurate and earlier detection of renal pathology than is …
Reproducibility evaluation of urinary peptide detection using CE-MS
In recent years, capillary electrophoresis coupled to mass spectrometry (CE-MS) has been
increasingly applied in clinical research especially in the context of chronic and age …
increasingly applied in clinical research especially in the context of chronic and age …