Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

We developed stable isotope labeling and mass spectrometry approaches to measure the
kinetics of multiple isoforms and fragments of tau in the human central nervous system …

Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …

In multiple neurodegenerative diseases, including Alzheimer's disease (AD), a prominent
pathological feature is the aberrant aggregation and inclusion formation of the microtubule …

Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease
and related human tauopathies. There is a growing body of evidence indicating that …

Alzheimer's disease (AD) is characterized by progressive memory loss and cognitive
function deficits. There are two major pathological hallmarks that contribute to the …

Tau is a protein that is highly enriched in neurons and was originally defined by its ability to
bind and stabilize microtubules. However, it is now becoming evident that the functions of …

Alzheimer's disease (AD) manifests along a spectrum of cognitive deficits and levels of
neuropathology. Genetic studies support a heterogeneous disease mechanism, with around …