Cell-penetrating peptides: design strategies beyond primary structure and amphipathicity

D Kalafatovic, E Giralt - molecules, 2017 - mdpi.com
Efficient intracellular drug delivery and target specificity are often hampered by the presence
of biological barriers. Thus, compounds that efficiently cross cell membranes are the key to …

The mechanism of action of pepR, a viral-derived peptide, against Staphylococcus aureus biofilms

SN Pinto, SA Dias, AF Cruz… - Journal of …, 2019 - academic.oup.com
Objectives To investigate the mechanism of action at the molecular level of pepR, a
multifunctional peptide derived from the Dengue virus capsid protein, against …

Nucleic acid delivery by cell penetrating peptides derived from dengue virus capsid protein: design and mechanism of action

JM Freire, AS Veiga, I Rego de Figueiredo… - The FEBS …, 2014 - Wiley Online Library
Cell penetrating peptides (CPP s) can be used as drug delivery systems for different
therapeutic molecules. In this work two novel CPP s, pep R and pep M, designed from two …

Intracellular nucleic acid delivery by the supercharged dengue virus capsid protein

JM Freire, AS Veiga, TM Conceicao, W Kowalczyk… - PloS one, 2013 - journals.plos.org
Supercharged proteins are a recently identified class of proteins that have the ability to
efficiently deliver functional macromolecules into mammalian cells. They were first …

siRNA-cell-penetrating peptides complexes as a combinatorial therapy against chronic myeloid leukemia using BV173 cell line as model

JM Freire, IR de Figueiredo, J Valle, AS Veiga… - Journal of Controlled …, 2017 - Elsevier
Chronic myeloid leukemia (CML) is a myeloproliferative disorder caused by a single gene
mutation, a reciprocal translocation that originates the Bcr-Abl gene with constitutive tyrosine …

Peptides as models for the structure and function of viral capsid proteins: Insights on dengue virus capsid

JM Freire, AS Veiga, BG de la Torre… - Peptide …, 2013 - Wiley Online Library
The structural organization of viral particles is among the most astonishing examples of
molecular self‐assembly in nature, involving proteins, nucleic acids, and, sometimes, lipids …

Transportan 10 improves the anticancer activity of cisplatin

R Izabela, R Jarosław, A Magdalena, R Piotr… - Naunyn-schmiedeberg's …, 2016 - Springer
The aim of this paper was to examine whether cell-penetrating peptides (CPPs) such as
transportan 10 (TP10) or protein transduction domain (PTD4) may improve the anticancer …

[HTML][HTML] Effects of cargo molecules on membrane perturbation caused by transportan10 based cell-penetrating peptides

L Vasconcelos, F Madani, P Arukuusk… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Cell-penetrating peptides with the ability to escape endosomes and reach the target are of
great value as delivery vectors for different bioactive cargoes and future treatment of human …

The consideration of indolicidin modification to balance its hemocompatibility and delivery efficiency

CW Tsai, WW Hu, CI Liu, RC Ruaan, BC Tsai… - International Journal of …, 2015 - Elsevier
Indolicidin (IL) is an antimicrobial peptide (AMP), which has been utilized as a cell
penetrating peptide (CPP) for drug delivery. However, the hemolysis restricts its clinical …

Methods for Structural Studies of CPPs

Ü Langel - CPP, Cell-Penetrating Peptides, 2023 - Springer
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