Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer's disease: The role of antioxidants in prevention and …

G Juszczyk, J Mikulska, K Kasperek, D Pietrzak… - Antioxidants, 2021 - mdpi.com
There is a growing body of scientific research showing the link between depression and
dementia in Alzheimer's disease (AD). The chronic stress contributes to the formation of …

Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease

M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

The therapeutic role of ketogenic diet in neurological disorders

D Pietrzak, K Kasperek, P Rękawek… - Nutrients, 2022 - mdpi.com
The ketogenic diet (KD) is a high-fat, low-carbohydrate and adequate-protein diet that has
gained popularity in recent years in the context of neurological diseases (NDs). The …

[HTML][HTML] Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease

DA Butterfield, MP Mattson - Neurobiology of disease, 2020 - Elsevier
Inheritance of apolipoprotein E4 (APOE4) is a major risk factor for development of
Alzheimer's disease (AD). This lipoprotein, in contrast to apoE2, has arginine residues at …

Invited Review: APOE at the interface of inflammation, neurodegeneration and pathological protein spread in Alzheimer's disease

M Tzioras, C Davies, A Newman… - Neuropathology and …, 2019 - Wiley Online Library
Despite more than a century of research, the aetiology of sporadic Alzheimer's disease (AD)
remains unclear and finding disease modifying treatments for AD presents one of the …

Roles of apoE4 on the pathogenesis in Alzheimer's disease and the potential therapeutic approaches

YY Sun, Z Wang, HC Huang - Cellular and molecular neurobiology, 2023 - Springer
Abstract The Apolipoprotein E ε4 (ApoE ε4) allele, encoding ApoE4, is the strongest genetic
risk factor for late-onset Alzheimer's disease (LOAD). Emerging epidemiological evidence …

A multi‐hit hypothesis for an APOE4‐dependent pathophysiological state

OG Steele, AC Stuart, L Minkley, K Shaw… - European Journal of …, 2022 - Wiley Online Library
The APOE gene encoding the Apolipoprotein E protein is the single most significant genetic
risk factor for late‐onset Alzheimer's disease. The APOE4 genotype confers a significantly …

The role of melatonin in targeting cell signaling pathways in neurodegeneration

M Shukla, V Chinchalongporn… - Annals of the New …, 2019 - Wiley Online Library
Neurodegenerative diseases are typified by neuronal loss associated with progressive
dysfunction and clinical presentation. Neurodegenerative diseases are characterized by the …

Optimization algorithms for computational systems biology

F Reali, C Priami, L Marchetti - Frontiers in Applied Mathematics and …, 2017 - frontiersin.org
Computational systems biology aims at integrating biology and computational methods to
gain a better understating of biological phenomena. It often requires the assistance of global …

[HTML][HTML] Neuroprotective Benefits of Rosmarinus officinalis and Its Bioactives against Alzheimer's and Parkinson's Diseases

D Kosmopoulou, MP Lafara, T Adamantidi… - Applied Sciences, 2024 - mdpi.com
Featured Application Utilization of Rosmarinus officinalis extracts and/or its bioactives as
ingredients in functional products, foods, cosmetics, and pharmaceuticals, with anti …