Sarcopenia, an age-associated decline in skeletal muscle mass coupled with functional
deterioration, may be exacerbated by obesity leading to higher disability, frailty, morbidity …

The tetracycline-controlled Tet-Off and Tet-On gene expression systems are used to regulate
the activity of genes in eukaryotic cells in diverse settings, varying from basic biological …

A targeted effort to identify novel neurotrophic factors for midbrain dopaminergic neurons
resulted in the isolation of GDNF (glial cell line-derived neurotrophic factor) from the …

Objective A 12‐month double‐blind sham‐surgery–controlled trial assessing adeno‐
associated virus type 2 (AAV2)‐neurturin injected into the putamen bilaterally failed to meet …

Alcohol use disorder (AUD) exacts enormous personal, social and economic costs globally.
Return to alcohol use in treatment-seeking patients with AUD is common, engendered by a …

Lipid rafts are small, dynamic membrane areas characterized by the clustering of selected
membrane lipids as the result of the spontaneous separation of glycolipids, sphingolipids …

Therapies capable of decelerating, or perhaps even halting, neurodegeneration in
Parkinson's disease (PD) remain elusive. Clinical trials of PD gene therapy testing the …

Objective: In an effort to account for deficiencies in axonal transport that limit the
effectiveness of neurotrophic factors, this study tested the safety and feasibility, in …

Chondroitinase ABC is a promising preclinical therapy that promotes functional
neuroplasticity after CNS injury by degrading extracellular matrix inhibitors. Efficient delivery …

Presynaptic increase in striatal dopamine is the primary dopaminergic abnormality in
schizophrenia, but the underlying mechanisms are not understood. Here, we hypothesized …