Cancer is a life-threatening disease caused by the uncontrolled division of cells, which
culminates in a solid mass of cells known as a tumor or liquid cancer. It is the leading cause …

Cancers evolve by a reiterative process of clonal expansion, genetic diversification and
clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are …

Patient-specific ex vivo models of human tumours that recapitulate the pathological
characteristics and complex ecology of native tumours could help determine the most …

Many cancers feature cellular hierarchies that are driven by tumor-initiating cancer stem
cells (CSC) and rely on complex interactions with the tumor microenvironment. Standard cell …

Tumour-associated macrophages (TAMs) are enriched in glioblastoma multiformes (GBMs)
that contain glioma stem cells (GSCs) at the apex of their cellular hierarchy. The correlation …

Tissue development and homeostasis are governed by the actions of stem cells. Multipotent
cells are capable of self-renewal during the course of one's lifetime. The accurate and …

Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of
glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report …

Glioblastoma multiforme (GBM), an aggressive tumor that typically exhibits treatment failure
with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within …

Glioblastoma is the most lethal primary brain tumor; however, the crosstalk between
glioblastoma stem cells (GSCs) and their supportive niche is not well understood. Here, we …

Both the perivascular niche (PVN) and the integration into multicellular networks by tumor
microtubes (TMs) have been associated with progression and resistance to therapies in …