We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

In recent years, it has become clear that brief, repeated presentations of hypoxia [ie, acute
intermittent hypoxia (AIH)] can boost the efficacy of more traditional therapeutic strategies in …

Incomplete spinal cord injuries (iSCI) leave spared synaptic pathways below the level of
injury. Intermittent hypoxia (IH) elicits plasticity in the spinal cord and strengthens spared …

A major cause of mortality after spinal cord injury is respiratory failure. In normal rats, acute
intermittent hypoxia (AIH) induces respiratory motor plasticity, expressed as diaphragm (Dia) …

While spinal cord injuries (SCIs) result in a vast array of functional deficits, many of which
are life threatening, the majority of SCIs are anatomically incomplete. Spared neural …

Respiratory failure is the main cause of death in amyotrophic lateral sclerosis (ALS). Since
no effective treatments to preserve independent breathing are available, there is a critical …

Daily acute intermittent hypoxia (dAIH) improves breathing capacity after C2 spinal
hemisection (C2HS) in rats. Since C2HS disrupts spinal serotonergic innervation below the …

High spinal cord injuries (SCIs) lead to permanent functional deficits, including respiratory
dysfunction. Patients living with such conditions often rely on ventilatory assistance to …

An important model of respiratory motor plasticity is phrenic long-term facilitation (pLTF), a
persistent increase in phrenic burst amplitude following acute intermittent hypoxia (AIH) …

New Findings What is the central question of this study? Does a single session of repeated
bouts of acute intermittent hypoxic breathing enhance the motoneuronal output of the limb …