[HTML][HTML] MicroRNAs as therapeutic targets in cardiovascular disease
B Laggerbauer, S Engelhardt - The Journal of Clinical …, 2022 - Am Soc Clin Investig
The discovery of microRNAs and their role in diseases was a breakthrough that inspired
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …
[HTML][HTML] Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches
J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …
coding transcripts with unknown function. There are several types of non-coding linear …
[HTML][HTML] A review of the molecular mechanisms underlying the development and progression of cardiac remodeling
L Schirone, M Forte, S Palmerio, D Yee… - … medicine and cellular …, 2017 - hindawi.com
Pathological molecular mechanisms involved in myocardial remodeling contribute to alter
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …
MicroRNA in cardiovascular biology and disease.
A Wojciechowska, A Braniewska… - … in Clinical & …, 2017 - search.ebscohost.com
MicroRNAs (miRNAs) are members of a non-coding RNA family. They act as negative
regulators of protein translation by affecting messenger RNA (mRNA) stability; they …
regulators of protein translation by affecting messenger RNA (mRNA) stability; they …
Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives
Recent research has demonstrated that the non-coding genome plays a key role in genetic
programming and gene regulation during development as well as in health and …
programming and gene regulation during development as well as in health and …
Interplay between miRNAs and human diseases
P Paul, A Chakraborty, D Sarkar… - Journal of cellular …, 2018 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous, non‐coding RNAs, which have evoked a great deal
of interest due to their importance in many aspects of homeostasis and diseases …
of interest due to their importance in many aspects of homeostasis and diseases …
[HTML][HTML] Mesenchymal stem cell-based therapy for cardiovascular disease: progress and challenges
L Bagno, KE Hatzistergos, W Balkan, JM Hare - Molecular Therapy, 2018 - cell.com
Administration of mesenchymal stem cells (MSCs) to diseased hearts improves cardiac
function and reduces scar. These effects occur via stimulation of endogenous repair …
function and reduces scar. These effects occur via stimulation of endogenous repair …
Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets
The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …
The war against heart failure: the Lancet lecture
E Braunwald - The Lancet, 2015 - thelancet.com
Heart failure is a global problem with an estimated prevalence of 38 million patients
worldwide, a number that is increasing with the ageing of the population. It is the most …
worldwide, a number that is increasing with the ageing of the population. It is the most …
MicroRNAs in cardiovascular disease
Micro-ribonucleic acids (miRNAs) are in the spotlight as post-transcriptional regulators of
gene expression. More than 1,000 miRNAs are encoded in the human genome. In this …
gene expression. More than 1,000 miRNAs are encoded in the human genome. In this …