Pathogenic animal trypanosomes affecting livestock have represented a major constraint to
agricultural development in Africa for centuries, and their negative economic impact is …

African trypanosomiasis is associated with Trypanosoma evansi, T. vivax, T. congolense,
and T. brucei pathogens in African animal trypanosomiasis (AAT) while T. b gambiense and …

With the incidence of sleeping sickness in decline and genuine progress being made
towards the WHO goal of eliminating sleeping sickness as a major public health concern …

Arsenicals were introduced as monotherapies for the treatment of human African
trypanosomiasis, or sleeping sickness, over 100 years ago. Toxicity has always been an …

Animal African trypanosomiasis (AAT), caused by Trypanosoma congolense and
Trypanosoma vivax, remains one of the most important livestock diseases in sub-Saharan …

African trypanosomiasis is a disease caused by Trypanosoma brucei parasites with limited
treatment options. Trypanosoma is unable to synthesize purines de novo and relies solely …

African trypanosomiasis is a deadly neglected disease caused by the extracellular parasite
Trypanosoma brucei. Current therapies are characterized by high drug toxicity and …

Nowadays, drug resistance in parasites is considered to be one of the foremost concerns in
health and disease management. It is interconnected worldwide and undermines the health …

The nucleoside antibiotic tubercidin displays strong activity against different target
organisms, but it is notoriously toxic to mammalian cells. The effects of tubercidin against T …

Drug resistance is one of the emerging and re-emerging epidemics affecting both veterinary
and public health sectors. Buparvaquone provides the most satisfactory means in the …