Circuits and functions of the lateral habenula in health and in disease

H Hu, Y Cui, Y Yang - Nature Reviews Neuroscience, 2020 - nature.com
The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …

Reward processing by the lateral habenula in normal and depressive behaviors

CD Proulx, O Hikosaka, R Malinow - Nature neuroscience, 2014 - nature.com
The brain reward circuit has a central role in reinforcing behaviors that are rewarding and
preventing behaviors that lead to punishment. Recent work has shown that the lateral …

The ventral pallidum: Subregion-specific functional anatomy and roles in motivated behaviors

DH Root, RI Melendez, L Zaborszky, TC Napier - Progress in neurobiology, 2015 - Elsevier
The ventral pallidum (VP) plays a critical role in the processing and execution of motivated
behaviors. Yet this brain region is often overlooked in published discussions of the …

βCaMKII in lateral habenula mediates core symptoms of depression

K Li, T Zhou, L Liao, Z Yang, C Wong, F Henn… - science, 2013 - science.org
The lateral habenula (LHb) has recently emerged as a key brain region in the
pathophysiology of depression. However, the molecular mechanism by which LHb becomes …

An excitatory synapse hypothesis of depression

SM Thompson, AJ Kallarackal, MD Kvarta… - Trends in …, 2015 - cell.com
Depression is a common cause of mortality and morbidity, but the biological bases of the
deficits in emotional and cognitive processing remain incompletely understood. Current …

Serotonergic modulation of the activity of mesencephalic dopaminergic systems: therapeutic implications

P De Deurwaerdère, G Di Giovanni - Progress in neurobiology, 2017 - Elsevier
Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …

A new control center for dopaminergic systems: pulling the VTA by the tail

R Bourdy, M Barrot - Trends in neurosciences, 2012 - cell.com
The tail of the ventral tegmental area (tVTA), also named the rostromedial tegmental nucleus
(RMTg), is a recently defined midbrain structure considered to exert a major inhibitory drive …

Anatomical and single-cell transcriptional profiling of the murine habenular complex

ML Wallace, KW Huang, D Hochbaum, M Hyun… - Elife, 2020 - elifesciences.org
The lateral habenula (LHb) is an epithalamic brain structure critical for processing and
adapting to negative action outcomes. However, despite the importance of LHb to behavior …

Braking dopamine systems: a new GABA master structure for mesolimbic and nigrostriatal functions

M Barrot, SR Sesack, F Georges, M Pistis… - Journal of …, 2012 - Soc Neuroscience
A new mesopontine structure exerting a strong influence on dopamine systems has recently
been defined: the tail of the ventral tegmental area/rostromedial tegmental nucleus …

[图书][B] The parental brain: mechanisms, development, and evolution

M Numan - 2020 - books.google.com
The Parental Brain: Mechanisms, Development, and Evolution presents a comprehensive
analysis of how the brain regulates parental behavior in nonhuman animals and in humans …