Thirty years after the discovery of its production by activated macrophages, our appreciation
of the diverse roles of nitric oxide (NO) continues to grow. Recent findings have not only …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

In inflammation, bacterial products and proinflammatory cytokines induce the formation of
large amounts of nitric oxide (NO) by inducible nitric oxide synthase (iNOS), and compounds …

1 The role of nitric oxide (NO) derived from constitutive and inducible nitric oxide synthase
(cNOS and iNOS) and its relationship to oxygen‐derived free radicals and prostaglandins …

N-(3-(Aminomethyl) benzyl) acetamidine (1400W) was a slow, tight binding inhibitor of
human inducible nitric-oxide synthase (iNOS). The slow onset of inhibition by 1400W …

Neutrophils are prominent participants in the joint inflammation of human rheumatoid
arthritis (RA) patients, but the extent of their role in the inductive phase of joint inflammation …

Neuroinflammation and associated neuronal dysfunction mediated by activated microglia
play an important role in the pathogenesis of Alzheimer disease (AD). Microglia are …

The production of superoxide and nitric oxide individually has been associated with the
development of several diseases but only recently has it been realised that interactions …

Hyaluronan (hyaluronic acid, HA) is a linear naturally occurring polysaccharide formed from
repeating disaccharide units of N-acetyl-D-glucosamine and D-glucuronate. Despite its …

Nitric oxide (NO) is produced in physiological and pathophysiological conditions by three
distinct isoforms of NO synthase (NOS): endothelial NOS (ecNOS), inducible NOS (iNOS) …