Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction?
AN Malik, A Czajka - Mitochondrion, 2013 - Elsevier
Mitochondrial dysfunction is central to numerous diseases of oxidative stress. Changes in
mitochondrial DNA (MtDNA) content, often measured as mitochondrial genome to nuclear …
mitochondrial DNA (MtDNA) content, often measured as mitochondrial genome to nuclear …
Effects of ionizing radiation on mitochondria
WWY Kam, RB Banati - Free Radical Biology and Medicine, 2013 - Elsevier
The current concept of radiobiology posits that damage to the DNA in the cell nucleus is the
primary cause for the detrimental effects of radiation. However, emerging experimental …
primary cause for the detrimental effects of radiation. However, emerging experimental …
Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly
J Mengel-From, M Thinggaard, C Dalgård, KO Kyvik… - Human genetics, 2014 - Springer
The role of the mitochondria in disease, general health and aging has drawn much attention
over the years. Several attempts have been made to describe how the numbers of …
over the years. Several attempts have been made to describe how the numbers of …
Mitochondrial dysfunction in autism
C Giulivi, YF Zhang, A Omanska-Klusek, C Ross-Inta… - Jama, 2010 - jamanetwork.com
Context Impaired mitochondrial function may influence processes highly dependent on
energy, such as neurodevelopment, and contribute to autism. No studies have evaluated …
energy, such as neurodevelopment, and contribute to autism. No studies have evaluated …
Mitochondrial dysfunction in atherosclerosis
NR Madamanchi, MS Runge - Circulation research, 2007 - Am Heart Assoc
Increased production of reactive oxygen species in mitochondria, accumulation of
mitochondrial DNA damage, and progressive respiratory chain dysfunction are associated …
mitochondrial DNA damage, and progressive respiratory chain dysfunction are associated …
Mitochondria, metabolism, and redox mechanisms in psychiatric disorders
Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …
Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway
M Kitada, S Kume, N Imaizumi, D Koya - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Despite the beneficial effects of resveratrol (RSV) on cardiovascular disease
and life span, its effects on type 2 diabetic nephropathy remain unknown. This study …
and life span, its effects on type 2 diabetic nephropathy remain unknown. This study …
Association of mitochondrial DNA levels with frailty and all-cause mortality
Mitochondrial function is altered with age and variants in mitochondrial DNA (mtDNA)
modulate risk for several age-related disease states. However, the association of mtDNA …
modulate risk for several age-related disease states. However, the association of mtDNA …
Mitochondrial involvement in psychiatric disorders
L Shao, MV Martin, SJ Watson, A Schatzberg… - Annals of …, 2008 - Taylor & Francis
Recent findings of mitochondrial abnormalities in brains from subjects with neurological
disorders have led to a renewed search for mitochondrial abnormalities in psychiatric …
disorders have led to a renewed search for mitochondrial abnormalities in psychiatric …
Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants
R Moreno-Loshuertos, R Acín-Pérez… - Nature …, 2006 - nature.com
Common mitochondrial DNA (mtDNA) haplotypes in humans and mice have been
associated with various phenotypes, including learning performance and disease …
associated with various phenotypes, including learning performance and disease …