Endothelial Dysfunctions in Blood–Brain Barrier Breakdown in Alzheimer's Disease: From Mechanisms to Potential Therapies

Q Yue, X Leng, N Xie, Z Zhang, D Yang… - CNS Neuroscience & …, 2024 - Wiley Online Library
Recent research has shown the presence of blood–brain barrier (BBB) breakdown in
Alzheimer's disease (AD). BBB is a dynamic interface consisting of a continuous monolayer …

Vitamin D and rosuvastatin alleviate type-II diabetes-induced cognitive dysfunction by modulating neuroinflammation and canonical/noncanonical Wnt/β-catenin …

M Muneeb, SM Mansou, S Saleh, RA Mohammed - PloS One, 2022 - journals.plos.org
Background Type-II diabetes mellitus (T2DM) is a major risk factor for cognitive impairment.
Protecting the brain environment against inflammation, and neurodegeneration, as well as …

Metabolic and Environmental Biomarkers in Mild Cognitive Impairment and Dementia: An Exploratory Study

AC Lyon, CF Lippa, AR Eiser - Journal of Integrative and …, 2024 - liebertpub.com
Objective: To determine the frequency with which suspected pathogenic factors, including
metals and metabolites that might contribute to Alzheimer's disease (AD), may be found in …

Impaired insulin signaling and diet-induced type 3 diabetes pathophysiology increase amyloid β expression in the Drosophila model of Alzheimer's disease

K Sharma, P Rai, MG Tapadia - … et Biophysica Acta (BBA)-Molecular Cell …, 2025 - Elsevier
Compelling evidence has strongly linked unregulated sugar levels to developing
Alzheimer's disease, suggesting Alzheimer's to be 'diabetes of the brain or 'type 3 diabetes …

Gut Microbial Metabolite, Sodium Butyrate Regulates The Blood-Brain Barrier Transport And Intra-Endothelial Accumulation Of Alzheimer'S Disease Amyloid-Beta …

V Veerareddy - 2024 - conservancy.umn.edu
Alzheimer's disease (AD) is a common type of dementia observed in the elderly with brain
amyloid beta (Aꞵ) deposits as one of its pathological hallmarks. Risk factors contributing to …