Erythropoiesis is a multi‐step process that involves the differentiation of hematopoietic stem
cells into mature red blood cells (RBCs). This process is regulated by several signaling …

The discovery of an identical mutation (V617F) of the JAK2 gene in patients with
polycythemia vera, essential thrombocythemia, and myelofibrosis—the principal …

Abstract The PI3K/AKT and mTOR signaling pathways are activated in acute myeloid
leukemia, including in the more immature leukemic populations. Constitutive PI3K activation …

Erythropoietin (EPO) is a glycoprotein cytokine known for its pleiotropic effects on various
types of cells and tissues. EPO and its receptor EPOR trigger signaling cascades …

Parkinson's disease is a common progressive and multifactorial neurodegenerative disease,
characterized by the loss of midbrain dopaminergic neurons. Numerous pathological …

Abstract The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is crucial to many
aspects of cell growth, survival and apoptosis, and its constitutive activation has been …

Erythropoiesis is a complex multistep process encompassing the differentiation of
hemopoietic stem cells to mature erythrocytes. The steps involved in this complex …

Erythropoietin (Epo) has long been known to be the principal hematopoietic growth factor
that regulates cellular proliferation and differentiation along the erythroid lineage. Recent …

Polycythemia vera (PV) is a myeloproliferative disorder arising in a multipotent
hematopoietic stem cell. The pathogenesis of PV remains poorly understood; however, the …

In addition to its regulatory function in the formation of red blood cells (erythropoiesis) in
vertebrates, Erythropoietin (Epo) contributes to beneficial functions in a variety of non …