Dendritic cells: from ontogenetic orphans to myelomonocytic descendants

JH Peters, R Gieseler, B Thiele, F Steinbach - Immunology today, 1996 - Elsevier
Although dendritic cells (DCs) and macrophages share a bone marrow origin, these cells
were long assumed to differentiate via discrete pathways. DCs have now been clearly …

Adoptive immunotherapy of cancer using monocyte-derived macrophages: rationale, current status, and perspectives

R Andreesen, B Hennemann… - Journal of leukocyte …, 1998 - academic.oup.com
Adoptive transfer of host defense cells may be able to correct an otherwise defective
generation of competent immune cells in patients with cancer. Ex vivo-grown cytotoxic …

Enhancement of antitumor immunity by CTLA-4 blockade

DR Leach, MF Krummel, JP Allison - Science, 1996 - science.org
One reason for the poor immunogenicity of many tumors may be that they cannot provide
signals for CD28-mediated costimulation necessary to fully activate T cells. It has recently …

Vaccination of melanoma patients with peptide-or tumorlysate-pulsed dendritic cells

FO Nestle, S Alijagic, M Gilliet, Y Sun, S Grabbe… - Nature medicine, 1998 - nature.com
Melanoma is the main cause of death in patients with skin cancer1. Cytotoxic T lymphocytes
(CTLs) attack melanoma cells in an HLA-restricted and tumor antigen-specific manner …

Engineered nucleic acids encoding a modified erythropoietin and their expression

JP Schrum, NB Afeyan, GJ Sieczkiewicz… - US Patent …, 2014 - Google Patents
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Terminally modified RNA

T Chakraborty, S Bancel, SG Hoge, A Roy… - US Patent …, 2017 - Google Patents
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Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells

L Piemonti, P Monti, M Sironi, P Fraticelli… - The Journal of …, 2000 - journals.aai.org
We studied the effects of 1α, 25-dihydroxyvitamin D 3 (1α, 25-(OH) 2 D 3) on differentiation,
maturation, and functions of dendritic cells (DC) differentiated from human monocytes in vitro …

Engineered nucleic acids and methods of use thereof

JP Schrum, S Bancel, NB Afeyan - US Patent 8,822,663, 2014 - Google Patents
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C (= O) C (NC (= O)
C (CCC (N)= O) NC (= O) C (CCC (O)= O) NC (= O) C (C (C) C) NC (= O) C (NC (= O) CN) C …

Modified polynucleotides for the production of biologics and proteins associated with human disease

S Bancel, T Chakraborty, A De Fougerolles… - US Patent …, 2015 - Google Patents
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Modified polynucleotides for the production of secreted proteins

T Chakraborty, A De Fougerolles - US Patent 9,192,651, 2015 - Google Patents
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