Beneficial effects of betaine: a comprehensive review

MK Arumugam, MC Paal, TM Donohue Jr, M Ganesan… - Biology, 2021 - mdpi.com
Simple Summary A large number of studies report that medicinal herbs and many food
ingredients protect against the development of liver disease because they possess …

Metabolic reprogramming of liver fibrosis

ME Delgado, BI Cárdenas, N Farran, M Fernandez - Cells, 2021 - mdpi.com
Liver fibrosis is an excessive and imbalanced deposition of fibrous extracellular matrix
(ECM) that is associated with the hepatic wound-healing response. It is also the common …

Apigenin-oxymatrine binary co-amorphous mixture: Enhanced solubility, bioavailability, and anti-inflammatory effect

B Li, Y Hu, T Wu, Y Feng, C Jiang, H Du, S Lu - Food Chemistry, 2022 - Elsevier
Apigenin (APG) is a functional ingredient in many foods, but its poor water solubility results
in low bioavailability. This study aimed at delivering APG and improving bioavailability by a …

Synergistic anti-inflammatory effect of gut microbiota and lithocholic acid on liver fibrosis

J Shao, T Ge, C Tang, G Wang, L Pang, Z Chen - Inflammation Research, 2022 - Springer
Background Bile acids can regulate liver disease progression by affecting the functions of
gut microbiota and immune cells. As the most potent natural agonist of G-protein coupled …

Hepatic stellate cells role in the course of metabolic disorders development–A molecular overview

N Bourebaba, K Marycz - Pharmacological Research, 2021 - Elsevier
Fibrosis is characterized by an abnormal accumulation of extracellular matrix (ECM)
constituents in the liver parenchyma that lead to hepatic cirrhosis. After liver injury, the …

Combination treatment with hydroxytyrosol and vitamin E improves NAFLD-related fibrosis

N Panera, MR Braghini, A Crudele, A Smeriglio… - Nutrients, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD)-related liver fibrosis results in the encapsulation of
injured liver parenchyma by a collagenous scar mainly imputable to hepatic stellate cells' …

Lipid based nanocarriers for effective drug delivery and treatment of diabetes associated liver fibrosis

SA Salunkhe, D Chitkara, RI Mahato, A Mittal - Advanced Drug Delivery …, 2021 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a cluster of several liver diseases like hepatic
steatosis, non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver (NAFL), liver …

The total polyphenolic glycoside extract of Lamiophlomis rotata ameliorates hepatic fibrosis through apoptosis by TGF-β/Smad signaling pathway

G Wan, Z Chen, L Lei, X Geng, Y Zhang, C Yang… - Chinese Medicine, 2023 - Springer
Background Hepatic fibrosis is characterized by the excessive deposition of extracellular
matrix (ECM) which is mainly secreted by activated hepatic stellate cells (HSCs) …

Network pharmacological analysis and experimental validation of the mechanisms of action of Si-Ni-san against liver fibrosis

S Wang, C Tang, H Zhao, P Shen, C Lin… - Frontiers in …, 2021 - frontiersin.org
Background: Si-Ni-San (SNS), a commonly used traditional Chinese medicine (TCM)
formula, has potency against liver diseases, such as hepatitis and non-alcoholic fatty liver …

Impact of dietary fat on the progression of liver fibrosis: lessons from animal and cell studies

F Jia, X Hu, T Kimura, N Tanaka - International journal of molecular …, 2021 - mdpi.com
Previous studies have revealed that a high-fat diet is one of the key contributors to the
progression of liver fibrosis, and increasing studies are devoted to analyzing the different …