Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

M Xu, Y Qi, G Liu, Y Song, X Jiang, B Du - ACS nano, 2023 - ACS Publications
Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …

Targeted drug delivery strategies for precision medicines

MT Manzari, Y Shamay, H Kiguchi, N Rosen… - Nature Reviews …, 2021 - nature.com
Progress in the field of precision medicine has changed the landscape of cancer therapy.
Precision medicine is propelled by technologies that enable molecular profiling, genomic …

Engineering precision nanoparticles for drug delivery

MJ Mitchell, MM Billingsley, RM Haley… - Nature reviews drug …, 2021 - nature.com
In recent years, the development of nanoparticles has expanded into a broad range of
clinical applications. Nanoparticles have been developed to overcome the limitations of free …

Biomedicine meets Fenton chemistry

Z Tang, P Zhao, H Wang, Y Liu, W Bu - Chemical reviews, 2021 - ACS Publications
Since the first connection between Fenton chemistry and biomedicine, numerous studies
have been presented in this field. Comprehensive presentation of the guidance from Fenton …

The use of alternative strategies for enhanced nanoparticle delivery to solid tumors

M Izci, C Maksoudian, BB Manshian… - Chemical …, 2021 - ACS Publications
Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a
decade. Classically, scientists have tried to improve NM delivery by employing passive or …

A framework for designing delivery systems

W Poon, BR Kingston, B Ouyang, W Ngo… - Nature …, 2020 - nature.com
The delivery of medical agents to a specific diseased tissue or cell is critical for diagnosing
and treating patients. Nanomaterials are promising vehicles to transport agents that include …

The entry of nanoparticles into solid tumours

S Sindhwani, AM Syed, J Ngai, BR Kingston… - Nature materials, 2020 - nature.com
The concept of nanoparticle transport through gaps between endothelial cells (inter-
endothelial gaps) in the tumour blood vessel is a central paradigm in cancer nanomedicine …

The role of ligands in the chemical synthesis and applications of inorganic nanoparticles

A Heuer-Jungemann, N Feliu, I Bakaimi… - Chemical …, 2019 - ACS Publications
The design of nanoparticles is critical for their efficient use in many applications ranging from
biomedicine to sensing and energy. While shape and size are responsible for the properties …

Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer

D Kalyane, N Raval, R Maheshwari, V Tambe… - Materials Science and …, 2019 - Elsevier
In tumorous tissues, the absence of vasculature supportive tissues intimates the formation of
leaky vessels and pores (100 nm to 2 μm in diameter) and the poor lymphatic system offers …

Progress and challenges towards targeted delivery of cancer therapeutics

D Rosenblum, N Joshi, W Tao, JM Karp… - Nature communications, 2018 - nature.com
Targeted delivery approaches for cancer therapeutics have shown a steep rise over the past
few decades. However, compared to the plethora of successful pre-clinical studies, only 15 …